国际肿瘤学杂志

国际肿瘤学杂志››2019,Vol. 46››Issue (9): 544-547.doi:10.3760/cma.j.issn.1673-422X.2019.09.007

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影像基因组学在肺癌中的研究进展

国建林，张传玉，于华龙，张在先

  1. 青岛大学附属医院放射科266000
  • 收稿日期:2019-07-09出版日期:2019-09-08发布日期:2019-09-08
  • 通讯作者:张传玉 E-mail:hangchuanyu0926@163.com

Progress of radiogenomics in lung cancer

Guo Jianlin, Zhang Chuanyu, Yu Hualong, Zhang Zaixian

  1. Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266000, China
  • Received:2019-07-09Online:2019-09-08Published:2019-09-08
  • Contact:Zhang Chuanyu E-mail:hangchuanyu0926@163.com

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摘要：影像基因组学旨在探究影像组学特征与基因组特征之间的联系，其在肺癌的个体化分子靶向治疗中显示出一定的价值，且具有无创性、可重复性及廉价性等优点。近年来，已有大量研究表明肺癌的影像组学特征对其驱动基因的突变状态具有较高的预测价值。尽管目前影像基因组学的应用仍存在不足，但是随着其不断发展和完善，今后其在肺癌的精准治疗中将会发挥日益重要的作用。

关键词:肺肿瘤,受体,表皮生长因子,影像组学,间变性淋巴瘤激酶

Abstract:Radiogenomics aims at investigating the relationship between radiomics features and genomic features, which has certain practical value in the individualized molecular targeted therapy. Meanwhile, it is noninvasive, repeatable and inexpensive. In recent years, a large number of studies have shown that radiomics features have certain predictive values for the mutation status of driver genes of lung cancer. The application of radiogenomics is insufficient at present, but with its continuous improvement and development, it will play an increasingly important role in the precise therapy of lung cancer in the future.

Key words:Lung neoplasms,Receptor, epidermal growth factor,Radiomics,Anaplastic lymphoma kinase