长非编码RNA在神经胶质瘤研究中的新进展

摘要/Abstract

摘要：

神经胶质瘤是最常见的原发性颅内肿瘤,其本质上是一种多基因异常疾病。长非编码RNA(lncRNA)是一类长度超过200个核苷酸的非编码基因,通过调控肿瘤相关基因的表达或相关信号通路在肿瘤的发生发展中发挥着重要作用。lncRNA在神经胶质瘤中异常表达有助于神经胶质瘤表型的多样性。深入研究异常表达的lncRNA在神经胶质瘤发病机制和病理分级中的潜在作用,有望为临床靶向治疗神经胶质瘤提供新的思路。

关键词:RNA,长链非编码,神经胶质瘤

Abstract:

Glioma is the most common primary intracranial tumor which is essentially a polygenic abnormal disease. Long non-coding RNA (lncRNA) is a class of noncoding genes with a length of more than 200 nucleotides. LncRNA plays an important role in tumorigenesis and development by regulating the expression of tumor-related genes or related signaling pathways. The abnormally expressions of lncRNA in gliomas contribute to the diversity of glioma phenotypes. In-depth study of the potential role of abnormally expressed lncRNA in the pathogenesis and pathological grading of gliomas will provide new ideas for clinical targeted treatment of gliomas.

Key words:RNA, long noncoding,Glioma

南阳, 钟跃. 长非编码RNA在神经胶质瘤研究中的新进展[J]. 国际肿瘤学杂志, 2020, 47(2): 98-102.

Nan Yang, Zhong Yue. New research advances of long non-coding RNA in glioma[J]. Journal of International Oncology, 2020, 47(2): 98-102.

参考文献37

[1]	南阳, 钟跃 . 恶性胶质瘤的分子靶向治疗[J]. 国际肿瘤学杂志, 2017,44(8):689-692. DOI: 10.3760/cma.j.issn.1673-422X.2017.09.012.
[2]	Louis DN, Perry A, Reifenberger G , et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary[J]. Acta Neuropathol, 2016,131(6):803-820. DOI: 10.1007/s00401-016-1545-1.
[3]	Inamura K . Major tumor suppressor and oncogenic non-coding RNAs: clinical relevance in lung cancer[J]. Cells, 2017, 6(2). pii: E12. DOI: 10.3390/cells6020012.
[4]	Hu L, Lv QL Chen , et al. Up-regulation of long non-coding RNA AB073614 predicts a poor prognosis in patients with glioma[J]. Int J Environ Res Public Health, 2016,13(4):433. DOI: 10.3390/ijerph13040433.
[5]	Li J, Wang YM, Song YL . Knockdown of long noncoding RNA AB073614 inhibits glioma cell proliferation and migration via affecting epithelial-mesenchymal transition[J]. Eur Rev Med Pharmacol Sci, 2016,20(19):3997-4002.
[6]	Pervan, CL. Smad-independent TGF-β2 signaling pathways in human trabecular meshwork cells[J]. Exp Eye Res, 2017,158:137-145. DOI: 10.1016/j.exer.2016.07.012.
[7]	Wang ZH, Guo XQ, Zhang QS , et al. Long non-coding RNA CCAT1 promotes glioma cell proliferation via inhibiting microRNA-410[J]. Biochem Biophys Res Commun, 2016,480(4):715-720. DOI: 10.1016/j.bbrc.2016.10.047.
[8]	Guo H, Hu G, Yang Q , et al. Knockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells[J]. Oncotarget, 2016,7(49):81806-81814. DOI: 10.18632/oncotarget.13242.
[9]	Zhang H, Wei DL, Wan L , et al. Highly expressed lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling[J]. Biochem Biophys Res Commun, 2017,482(4):1219-1225. DOI: 10.1016/j.bbrc.2016.12.016.
[10]	Zheng J, Liu X, Wang P , et al. CRNDE promotes malignant progression of glioma by attenuating miR-384/PIWIL4/STAT3 axis[J]. Mol Ther, 2016,24(7):1199-1215. DOI: 10.1038/mt.2016.71.
[11]	Kiang KM, Zhang XQ, Zhang GP , et al. CRNDE expression positively correlates with EGFR activation and modulates glioma cell growth[J]. Target Oncol, 2017,12(3):353-363. DOI: 10.1007/s11523-017-0488-3.
[12]	Wang S, Hui Y, Li X , et al. Silencing of lncRNA CCDC26 restrains the growth and migration of glioma cells in vitro and in vivo via targeting miR-203[J]. Oncol Res, 2018,26(8):1143-1154. DOI: 10.3727/096504017X14965095236521.
[13]	Chen X, Gao Y, Li D , et al. LncRNA-TP53TG1 participated in the stress response under glucose deprivation in glioma[J]. J Cell Biochem, 2017,118(12):4897-4904. DOI: 10.1002/jcb.26175.
[14]	Zhou Y, Wang DL, Pang Q . Long noncoding RNA SPRY4-IT1 is a prognostic factor for poor overall survival and has an oncogenic role in glioma[J]. Eur Rev Med Pharmacol Sci, 2016,20(14):3035-3039.
[15]	Zhang R, Jin H, Lou F . The long non-coding RNA TP73-AS1 interacted with miR-142 to modulate brain glioma growth through HMGB1/RAGE pathway[J]. J Cell Biochem, 2018,119(4):3007-3016. DOI: 10.1002/jcb.26021.
[16]	Deguchi S, Katsushima K, Hatanaka A , et al. Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis[J]. Oncogene, 2017,36(32):4629-4640. DOI: 10.1038/onc.2017.88.
[17]	Cheng Z, Li Z, Ma K , et al. Long non-coding RNA XIST promotes glioma tumorigenicity and angiogenesis by acting as a molecular sponge of miR-429[J]. J Cancer, 2017,8(19):4106-4116. DOI: 10.7150/jca.21024.
[18]	Lv QL, Hu L, Chen SH , et al. A long noncoding RNA ZEB1-AS1 promotes tumorigenesis and predicts poor prognosis in glioma[J]. Int J Mol Sci, 2016,17(9):1431. DOI: 10.3390/ijms17091431.
[19]	Gao K, Ji Z, She K , et al. Long non-coding RNA ZFAS1 is an unfavourable prognostic factor and promotes glioma cell progression by activation of the Notch signaling pathway[J]. Biomed Pharmacother, 2017,87:555-560. DOI: 10.1016/j.biopha.2017.01.014.
[20]	Hu G W, Wu L, Kuang W , et al. Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway[J]. Gene, 2017,610:24-31. DOI: 10.1016/j.gene.2017.02.006.
[21]	Chen ZH, Hu HK, Zhang CR , et al. Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells[J]. Am J Transl Res, 2016,8(10):4106-4119.
[22]	Zhao W, Sun C, Cui Z . A long noncoding RNA UCA1 promotes proliferation and predicts poor prognosis in glioma[J]. Clin Transl Oncol, 2017,19(6):735-741. DOI: 10.1007/s12094-016-1597-7.
[23]	Ke J, Yao Y, Zheng J , et al. Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326[J]. Oncotarget, 2015,6(26):21934-21949. DOI: 10.18632/oncotarget.4290.
[24]	Xu C, He T, Li Z , et al. Regulation of HOXA11-AS/miR-214-3p/EZH2 axis on the growth, migration and invasion of glioma cells[J]. Biomed Pharmacother, 2017,95:1504-1513. DOI: 10.1016/j.biopha.2017.08.097. doi:10.1016/j.biopha.2017.08.097
[25]	Zhu Y, Zhang X, Qi L , et al. HULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K/AKT/mTOR signaling pathway in human gliomas[J]. Oncotarget, 2016,7(12):14429-14440. DOI: 10.18632/oncotarget.7418.
[26]	Wu X, Wang Y, Yu T , et al. Blocking MIR155HG/miR-155 axis inhibits mesenchymal transition in glioma[J]. Neuro Oncol, 2017,19(9):1195-1205. DOI: 10.1093/neuonc/nox017.
[27]	Zhen L, Yun-Hui L, Hong-Yu D , et al. Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p/c-Met axis[J]. Tumour Biol, 2016,37(1):673-683. DOI: 10.1007/s13277-015-3843-y.
[28]	Gong W, Zheng J, Liu X , et al. Knockdown of NEAT1 restrained the malignant progression of glioma stem cells by activating microRNAlet-7e[J]. Oncotarget, 2016,7(38):62208-62223. DOI: 10.18632/oncotarget.11403.
[29]	Xue W, Chen J, Liu X , et al. PVT1 regulates the malignant behaviors of human glioma cells by targeting miR-190a-5p and miR-488-3p[J]. Biochim Biophys Acta Mol Basis Dis, 2018,1864(5 Pt A):1783-1794. DOI: 10.1016/j.bbadis.2018.02.022.
[30]	Liao Y, Shen L, Zhao H , et al. LncRNA CASC2 interacts with miR-181a to modulate glioma growth and resistance to TMZ through PTEN pathway[J]. J Cell Biochem, 2017,118(7):1889-1899. DOI: 10.1002/jcb.25910.
[31]	Zhang S, Wang W, Liu G , et al. Long non-coding RNA HOTTIP promotes hypoxia-induced epithelial-mesenchymal transition of malignant glioma by regulating the miR-101/ZEB1 axis[J]. Biomed Pharmacother, 2017,95:711-720. DOI: 10.1016/j.biopha.2017.08.133.
[32]	Han Y, Wu Z, Wu T , et al. Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling[J]. Cell Death Dis, 2016,7:e2123. DOI: 10.1038/cddis.2015.407.
[33]	Fu Z, Luo W, Wang J , et al. Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma[J]. Biochem Biophys Res Commun, 2017,492(3):480-486. DOI: 10.1016/j.bbrc.2017.08.070.
[34]	Yue H, Zhu J, Xie S , et al. MDC1-AS, an antisense long noncoding RNA, regulates cell proliferation of glioma[J]. Biomed Pharmacother, 2016,81:203-209. DOI: 10.1016/j.biopha.2016.03.002.
[35]	Qin N, Tong GF, Sun LW , et al. Long noncoding RNA MEG3 suppresses glioma cell proliferation, migration, and invasion by acting as a competing endogenous RNA of miR-19a[J]. Oncol Res, 2017,25(9):1471-1478. DOI: 10.3727/096504017X148866-89179993.
[36]	Li J, An G, Zhang M , et al. Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells[J]. Biochem Biophys Res Commun, 2016,477(4):743-748. DOI: 10.1016/j.bbrc.2016.06.129. doi:10.1016/j.bbrc.2016.06.129
[37]	Shang C, Guo Y, Hong Y , et al. Long non-coding RNA TUSC7, a target of miR-23b, plays tumor-suppressing roles in human gliomas[J]. Front Cell Neurosci, 2016,10:235. DOI: 10.3389/fncel.2016.00235.