国际肿瘤学杂志

国际肿瘤学杂志››2011,Vol. 38››Issue (8): 582-584.

• 综述 •上一篇下一篇

细胞间隙连接异常与肿瘤

王娟, 夏娟

  1. 广州，中山大学光华口腔医学院黏膜科
  • 出版日期:2011-08-08发布日期:2011-08-29
  • 通讯作者:王娟# E-mail:王娟wangj0504@gmail.com

Aberrant gap junction and tumor

WANG Juan, XIA Juan

    • Online:2011-08-08Published:2011-08-29

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    被引次数

    3

    摘要：间隙连接是相邻细胞间进行物质和信息交换的跨膜蛋白通道结构，是细胞间隙连接通讯的结构基础。间隙连接在多种肿瘤中常发生异常改变，与肿瘤的发生、转移等密切相关。将间隙连接作为靶点设计抗癌新药物，将为肿瘤治疗提供新方向。

    关键词:连接蛋白类,缝隙结合部,肿瘤,细胞间通讯

    Abstract:Gap junctions are membrane structures made of intercellular channels that allow direct exchange of material and information between adjacent cells. It is the structural basis of gap junctional intercellular communication. A lot of data suggest that aberrant gap junction often involves in variety of cancer models, it relatives with tumorgenesis and metastasis. It may provide a novel therapeutic target for tumor treatment when utilize connexin to design new anti-cancer drug.

    Key words:Connexins,Gap junctions,Neoplasms,Cell communication