国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (1): 31-34.

• 综述 •上一篇下一篇

雌激素受体共调节因子在乳腺癌内分泌治疗抵抗中的作用

叶娟, 张灏

  1. 515041广东省汕头大学医学院附属肿瘤医院中西医结合科； 汕头大学医学院肿瘤研究中心
  • 出版日期:2012-01-08发布日期:2013-11-11
  • 通讯作者:张灏, E-mail：haozhang@stu.edu.cn E-mail:haozhang@stu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目81071736；国家自然科学基金资助项目30973508；教育部高等学校博士点专项基金资助项目20104402110005；广东省高等学校人才引进项目[2009]109；汕头市科技计划重点项目[2009]387

Estrogen receptorcoregulators and their roles in resistance to endocrine therapy of breast cancer

YE Juan, ZHANG Hao

  1. Department of Integrated Medicine, Cancer Hospital of Shantou University Medical College＆Cancer Research Center, Shantou University Medical College, Shantou 515041, China

  • Online:2012-01-08Published:2013-11-11
  • Contact:Corresponding author: ZHANG Hao, E-mail: haozhang@stu.edu.cn E-mail:haozhang@stu.edu.cn

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摘要：雌激素受体（ER）共调节因子通过调节ER的转录活性，影响由ER介导的靶基因的转录及翻译。除在乳腺癌的发生、进展和转移中发挥重要作用外，ER共调节因子通过其基因组和非基因组功能也与乳腺癌的内分泌治疗反应密切相关。

关键词:乳腺肿瘤,受体,雌激素,抗药性,肿瘤

Abstract:The estrogen receptor (ER) coregulators regulate the transcriptional activities of ER, and then affect the transcription and translation of target genes mediated by ER. ER coregulators not only plays an important role in the initiation, progression and metastasis of breast cancer, but also involved in the response to endocrine therapy of breast cancer via the genomic and nongenomic function.