国际肿瘤学杂志››2012,Vol. 39››Issue (11): 806-808.

• 综述 •上一篇下一篇

人食管癌相关基因4与肿瘤

洪超群, 游颜杰, 黄继红

  1. 515041汕头大学医学院附属肿瘤医院(洪超群、黄继红);汕头大学医学院肿瘤研究中心(游颜杰)
  • 出版日期:2012-11-08发布日期:2012-11-16
  • 通讯作者:游颜杰, E-mail: youyanjie@163.com E-mail:youyanjie@163.com
  • 基金资助:

    广东省医学科研基金资助项目(B2012261)

Esophageal cancer related gene 4 in tumor

HONG Chao-Qun, YOU Yan-Jie, HUANG Ji-Hong

  1. Cancer Research Laboratory, Cancer Hospital of Shantou University Medical College, Shantou 515041, China
  • Online:2012-11-08Published:2012-11-16
  • Contact:Corresponding author:YOU Yan-jie, E-mail:youyanjie@163.com E-mail:youyanjie@163.com

摘要:人食管癌相关基因4(ECRG4)通过与NF-κB与p53相互作用参与调节细胞周期从而发挥抑癌基因的功能。研究表明ECRG4表达下调与多种肿瘤的发生发展密切相关,提示ECRG4有希望成为针对恶性肿瘤的潜在分子诊断标志物和治疗靶点。

关键词:基因,肿瘤抑制,肿瘤,肿瘤标记,生物学,诊断

Abstract:Esophageal cancer related gene 4 (ECRG4) serves as a tumor suppressor gene through interacting with NF-κB and p53 pathways. Multiple studies have demonstrated that the down-regulated expression of ECRG4 occurs in a variety of cancer types, indicating a potential application of ECRG4 as a molecular diagnostic marker as well as a therapeutic target

Key words:font-size: 12pt">Genes, tumor suppressor,Neoplasms,Tumor markers, biological,Diagnosis