国际肿瘤学杂志››2012,Vol. 39››Issue (11): 818-820.

• 综述 •上一篇下一篇

Cullin1蛋白与恶性肿瘤

王维民, 邓建良, 周炎

  1. 214200江苏大学附属宜兴医院肿瘤内科(王维民、邓建良);江苏大学附属宜兴医院肿瘤内科(周炎)
  • 出版日期:2012-11-08发布日期:2012-11-16
  • 通讯作者:周炎, E-mail: staff260@yxph.com E-mail:staff260@yxph.com
  • 基金资助:

    江苏省恶性肿瘤生物标志物与防治重点实验室开放课题(11ZLKF09)

Cullin1 and malignant tumors

WANG Wei-Min, DENG Jian-Liang, ZHOU Yan

  1. Department of Medical Oncology, Yixing Hospital, Jiangsu University, Yixing 214200 ,China
  • Online:2012-11-08Published:2012-11-16
  • Contact:Corresponding author: ZHOU Yan,E-mail: staff260@yxph.com E-mail:staff260@yxph.com

摘要:Cullin1是cullin基因组中的一个成员,Cullin1所组装的复合体具有典型的泛素连接酶活性,介导许多细胞周期蛋白尤其是癌相关蛋白的降解过程,有效地调节着细胞周期进程。Cullin1在恶性肿瘤的发生发展中起到很重要的作用。

关键词:肿瘤,Cullin1

Abstract:Cullin1 is a member of the cullin genome. The cullin1 assembly complex has typical ubiquitin ligase activity, and mediates cell cycle proteins, especially cancer-associated protein degradation process, an then effectively regulates the cell cycle progression. Cullin1 play an important role in the genesis and development of malignant tumors.

Key words:Neoplasms,Cullin1