国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (12): 905-907.

• 综述 •上一篇下一篇

Ⅲ型干扰素的抗肿瘤作用

王晴, 张璐, 沈倩妮, 朱薿, 罗凡, 侯炜

  1. 430071病毒学国家重点实验室武汉大学基础医学院
  • 出版日期:2012-12-08发布日期:2012-11-15
  • 通讯作者:侯炜，E-mail: houwei@whu.edu.cn E-mail:houwei@whu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目（30972754）；教育部留学回国人员科研启动基金资助项目【教外司留2010（609号）】

Anti-tumor effect of Type Ⅲ interferon

WANG Qing, ZHANG Lu, SHEN Qian-Ni, ZHU Ni, LUO Fan, HOU Wei

  1. State Key Laboratory of Virology; School of Basic Medical Science, Wuhan University , Wuhan 430071, China
  • Online:2012-12-08Published:2012-11-15
  • Contact:Corresponding author: HOU Wei, E-mail: houwei@whu.edu.cn E-mail:houwei@whu.edu.cn

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1587

被引次数

4

摘要：研究发现Ⅲ型干扰素（IFN-λ）具有抗黑色素瘤、肝细胞癌、食管癌、纤维素瘤等的作用。IFN-λ不仅能抑制黑色素瘤的转移，还可引起细胞凋亡；组成性表达的IFN-λ使自然杀伤细胞活化，从而影响肝细胞癌的生长；在食管癌中，IFN-λ能诱导G1期细胞的停滞或直接导致细胞凋亡；IFN-λ可通过诱导固有免疫和适应性免疫反应来抑制体内纤维肉瘤的生长。这些抗肿瘤机制的研究为IFN-λ运用于肿瘤临床治疗提供了新的思路。

关键词:干扰素类,肿瘤

Abstract:It is reported that type Ⅲ interferon (IFN-λ) has an anti-tumor effect on melanoma, hepatocellular carcinoma, esophageal carcinoma and fibrosarcoma in recent years. IFN-λ could not only inhibit melanoma metastasis, but also induce cell apoptosis; its constitutively expression could activate natural killer cells, affecting hepatocellular carcinoma growth; IFN-λ could induce cells of G1phase in esophageal carcinoma directly to stagnation or apoptosis; IFN-λ could cause native and adaptive immune response to suppress fibrosarcoma growth. Research on the anti-tumor mechanisms of IFN-λ will provide new ideas for clinical tumor therapy.

Key words:Interferons,Neoplasms