国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (3): 182-186.

• 综述 •上一篇下一篇

EZH2与肿瘤的关系

白洁, 帅晓明, 陶凯雄

  1. 430022武汉，华中科技大学同济医学院附属协和医院胃肠外科
  • 出版日期:2012-03-08发布日期:2012-02-24

EZH2 gene and cancer

BAI Jie, SHUAI Xiao-Ming, TAO Kai-Xiong

  1. Department of Gastrointestinal Surgery,Wuhan Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
  • Online:2012-03-08Published:2012-02-24

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3252

被引次数

3

摘要：EZH2是PRC2的一个亚基，通过催化组蛋白H3第27位赖氨酸三甲基化抑制基因表达。在前列腺癌、乳腺癌、膀胱癌及胃癌等多种肿瘤中都有高表达，与肿瘤的恶性进程、侵袭性、转移能力关系密切。随着对其在肿瘤中分子功能、上下游调控机制、临床病理特点的深入了解，EZH2有望做为靶点，为肿瘤治疗提供新的途径。

关键词:color: green,font-family: 宋体,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-bidi-font-family: 宋体,mso-font-kerning: 1.0pt">肿瘤,治疗,EZH2

Abstract:EZH2 is the catalytic subunit of polycomb repressive complex 2 (PRC2), which represses gene expression bycatalyzinglysine 27 of histone H3. It is overexpressed in prostate cancer, breast cancer, bladder cancer, gastric cancer and several other cancers.There is a close correlation between overexpression of EZH2 and progression of malignancy, invasion and migration of cancer cells. With a thorough understanding of the function, up and down stream regulatory mechanism and clinicopathological features, EZH2 will be expected to as a target and provide a new way for the treatment of cancers.

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