国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (3): 200-202.

• 综述 •上一篇下一篇

表皮生长因子受体Ⅲ型突变体与恶性胶质瘤靶向治疗

颜红莲,章龙珍

  1. 221000徐州医学院研究生院
  • 出版日期:2012-03-08发布日期:2012-02-24
  • 通讯作者:章龙珍,E-mail:jsxzzlz@126.com E-mail:jsxzzlz@126.com
  • 基金资助:

    国家自然科学资金资助项目（81071831）

Epidermal growth factor receptor Ⅲ variant and targeted therapy of glioblastoma

YAN Hong-Lian, ZHANG Long-Zhen

  1. Institute of Graduate,Xuzhou Medical College,Xuzhou 221002,China
  • Online:2012-03-08Published:2012-02-24
  • Contact:ZHANG Long-zhen,E-mail: jsxzzlz@126.com E-mail:jsxzzlz@126.com

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摘要：表皮生长因子受体Ⅲ型突变体（EGFRvⅢ）在脑胶质瘤中呈高表达，可以作为一个靶点来治疗肿瘤。针对EGFRvⅢ的抗恶性胶质瘤治疗包括RNA干扰、免疫治疗等方法。

关键词:color: green,font-family: 宋体,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-bidi-font-family: 'Times New Roman',mso-no-proof: yes">受体,表皮生长因子,神经胶质瘤,分子靶向治疗

Abstract:Epidermal growth factor receptor Ⅲ variant (EGFRvⅢ) is high expressed in gliomas, which can be used as a target to treat cancer. The therapy methods of glioblastoma targeted for EGFRvⅢ include RNA interference, immunotherapy, etc.

Key words:color: green,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-no-proof: yes">Receptor, epidermal growth factor,color: green,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-no-proof: yes">Glioma,color: green,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-no-proof: yes">Molecular targeted therapy