国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (3): 206-208.

• 综述 •上一篇下一篇

BRAFV600E基因突变与甲状腺乳头状癌

焦小平,王圣应

  1. 233004蚌埠医学院第一附属医院肿瘤外一科
  • 出版日期:2012-03-08发布日期:2012-02-24
  • 通讯作者:王圣应，E-mail:wangshengying61@yahoo.com.cn

BRAFV600Egene mutation and papillary thyroid cancer

JIAO Xiao-Ping, WANG Sheng-Ying

  1. The First Department of Surgery Oncology,First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
  • Online:2012-03-08Published:2012-02-24
  • Contact:WANG Sheng-ying, E-mail: wangshengying61@yahoo.com.cn

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摘要：BRAFV600E基因突变是甲状腺乳头状癌中最常见的遗传学事件，是浸润性肿瘤临床表型和预后不佳的指标，BRAFV600E因突变检测对甲状腺恶性结节的术前鉴别诊断及指导甲状腺癌的手术切除范围、判断患者预后、指导术后后继治疗均有重要的指导意义。

关键词:color: black,font-family: 宋体,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-bidi-font-family: 'Times New Roman',mso-font-kerning: 1.0pt,mso-hansi-font-family: 'Times New Roman',mso-ascii-font-family: 'Times New Roman'">甲状腺肿瘤,腺癌,乳头状,点突变

Abstract:The BRAFV600Emutation in papillary thyroid carcinoma is the most common genetic event, which is an invasive tumor clinical phenotype and a poor prognosis indicator. The BRAFV600Emutation detection has an important guiding significance for the differential diagnosis of malignant thyroid nodules on preoperative, guiding the surgical resection range of thyroid cancer, judging the patient’s prognosis and guiding the subsequent treatment of postoperative

Key words:color: black,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt">Thyroid neoplasms,Adenocarcinoma, papillary,Point mutation