国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (5): 341-344.

• 综述 •上一篇下一篇

星形胶质细胞上调基因1在恶性肿瘤中的研究

杜成，谢晓冬

  1. 沈阳军区总医院肿瘤科
  • 出版日期:2012-05-08发布日期:2012-05-02
  • 通讯作者:谢晓冬，E-mail: xiexiaodong@csco.org.cn E-mail:xiexiaodong@csco.org.cn.

Astrocyte elevated gene 1 in malignant tumor

DU Cheng, XIE Xiao-dong

  1. General Hospital of Shenyang Military Region, Shenyang 110840, China
  • Online:2012-05-08Published:2012-05-02
  • Contact:XIE Xiao-dong, E-mail: xiexiaodong@csco.org.cn. E-mail:xiexiaodong@csco.org.cn.

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摘要：近年研究表明，星形胶质细胞上调基因-1（AEG-1）几乎高表达于所有恶性实体瘤中并与不良预后密切相关，成为多种肿瘤的预后标志物。作为强碱性蛋白，AEG-1具有跨膜结构域和多重核定位信号，在包膜、胞质和胞核中均有表达。作为癌基因，AEG-1在肿瘤细胞增殖、凋亡、迁移、黏附、侵袭、肿瘤血管生成和化疗耐药等多种恶性生物学行为中发挥重要作用。AEG-1在肿瘤发生、发展中的关键作用使其可能成为肿瘤治疗的新靶点。

关键词:肿瘤,癌基因

Abstract:Recent studies suggest that astrocyte elevated gene 1 (AEG-1) is almost highly expressed in all types of malignant solid tumors and correlates with poor prognosis, which becomes a prognostic marker for many kinds of tumors. As a strongly basic protein, AEG-1 possesses a transmembrane domain and multiple nuclear localization signals. It is present in the cell membrane, cytoplasm and nucleus. As an oncogene, AEG-1 palys an important role in a virety of malignant biological behaviors of cancer, which range from cell proliferation, apoptosis, migration, adhesion, invasion to tumor angiogenesis and chemotherapy resistance. Its critical role in tumor genesis and progression has made it a potential therapeutic target.

Key words:Neoplasms,Oncogenes