国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (5): 384-386.

• 综述 •上一篇下一篇

肝细胞生长因子及其受体在多发性骨髓瘤中的研究进展

胡成琳，傅雷华，陈林

  1. 重庆医科大学附属第二医院血液内科
  • 出版日期:2012-05-08发布日期:2012-05-02
  • 通讯作者:陈林, E-mail: chenlincq@sina.com E-mail:chenlincq@sina.com

Hepatocyte growth factor and its receptor in multiple myeloma

HU Cheng-lin, FU Lei-hua, CHEN Lin

  1. Department of Hematology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
  • Online:2012-05-08Published:2012-05-02
  • Contact:CHEN Lin, E-mail: chenlincq@sina.com E-mail:chenlincq@sina.com

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摘要：肝细胞生长因子（HGF）是一个多功能的细胞因子，作用于细胞表面的跨膜受体c-Met发挥生物学作用。许多肿瘤的生长、侵袭和转移都与HGF-c-Met信号转导通路异常有关。HGF及其受体c-Met与多发性骨髓瘤（MM）的发生、转移、侵袭及预后关系密切

关键词:肝细胞生长因子,多发性骨髓瘤

Abstract:Hepatocyte growth factor (HGF), a multifunctional cytokine, plays a biological role through acting on the cell surface transmembrane receptor c-Met. The growth, invasion and metastasis of many tumors are associated with the abnormalities of HGFc-Met signaling pathway. Studies found that HGF and its receptor c-Met have close relations with the occurrence, metastasis, invasion and prognosis of multiple myeloma.

Key words:Hepatocyte growth factor,Multiple myeloma