国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (8): 573-575.

• 综述 •上一篇下一篇

甲状腺素与肿瘤血管生成

胡杨志,潘运龙,赵晓旭,覃莉,丁晖

  1. 广州,暨南大学第一临床学院普外科（胡杨志、潘运龙、赵晓旭、丁晖）,医学院组织胚胎教研室（覃莉）
  • 出版日期:2012-08-29发布日期:2012-08-29
  • 通讯作者:潘运龙，E-mail：tpanyl@jnu.edu.cn E-mail:tpanyl@jnu.edu.cn

Thyroid hormone and tumor angiogenesis

HU Yang-Zhi, PAN Yun-Long, ZHAO Xiao-Xu, QIN Li, DING Hui

  1. *Department of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  • Online:2012-08-29Published:2012-08-29
  • Contact:PAN Yun-long, E-mail: tpanyl@jnu.edu.cn E-mail:tpanyl@jnu.edu.cn

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摘要：甲状腺素是调节人体细胞分化、生长及代谢的重要激素。研究显示，甲状腺素可以与细胞表面的整合素ανβ3受体结合，参与肿瘤血管生成的过程。而其结构类似物四碘甲腺乙酸则可以通过抑制甲状腺素与整合素ανβ3结合而产生抑制肿瘤血管生成的过程。对甲状腺素促肿瘤血管生成作用的研究，将为肿瘤分子靶向治疗提供了新的思路。

关键词:甲状腺素,肿瘤,靶向治疗

Abstract:Thyroid hormone is an important hormone for regulating cell differentiation, growth and metabolism. Many studies have shown that thyroid hormone can induce turmor angiogenesis after binding with the integrin ανβ3 receptor at cell surface. Tetraiodothyroacetic acid is the analogue of thyroid hormone, and can inhibit tumor angiogenesis by inhibiting the binding of thyroid hormone with integrin ανβ3. Studying the role of thyroid hormone in promoting tumor angiogenesis may provide a new approach for molecular targeted therapy of tumor.

Key words:Thyroxine,Neoplasms,Targeted therapy