国际肿瘤学杂志››2012,Vol. 39››Issue (8): 576-579.

• 综述 •上一篇下一篇

哺乳动物雷帕霉素靶蛋白抑制剂与肿瘤治疗

李欣,杨作成

  1. 410013长沙,中南大学湘雅三医院儿科
  • 出版日期:2012-08-29发布日期:2012-08-29
  • 通讯作者:杨作成,E-mail: yang_zcr@126.com E-mail:yang_zcr@126.com
  • 基金资助:

    国家自然科学基金资助项目(30973233)

Mammalian target of rapamycin inhibitors and tumor therapy

LI Xin, YANG Zuo-Cheng-

  1. Department of Pediatrics, the Third Hospital of Xiangya Medical School, Central South University, Changsha 410013, China
  • Online:2012-08-29Published:2012-08-29
  • Contact:YANG Zuo-cheng, E-mail: yang_zcr@126.com E-mail:yang_zcr@126.com

摘要:哺乳类动物雷帕霉素靶蛋白(mTOR)抑制剂的抗肿瘤作用已被熟知,传统的mTOR抑制剂包括雷帕霉素及其衍生物,早期已应用于临床。目前mTOR小分子抑制剂如磷脂酰肌醇激酶3激酶(PI3K)/mTOR双重抑制剂、Torin1等陆续被发现在肿瘤治疗中有着独特的作用。

关键词:肿瘤,抗肿瘤药,蛋白质丝氨酸苏氨酸激酶

Abstract:Mammalian target of rapamycin(mTOR) inhibitors have the antitumor effect, which have been known early. The traditional mTOR inhibitors include rapamycin and its derivatives, which have been applied in clinical use early. Nowadays, some new small molecule inhibitors such as the PI3K/mTOR duel inhibitor, Torin1, one after another are found to play a unique role in the tumor therapy.

Key words:Neoplasms,Antineoplastic agents,TOR serinethreonine kinases