国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (10): 726-729.

• 综述 •上一篇下一篇

MiR-494在肿瘤中的作用

黎明春, 吴爱兵, 杨志雄

  1. 524001湛江， 广东医学院附属医院肿瘤中心一区

  • 出版日期:2013-10-08发布日期:2013-09-23
  • 通讯作者:杨志雄，E-mail：yangzhixiong068@126.com E-mail:yangzhixiong068@126.com
  • 基金资助:

    广东省科技计划项目（2011B031800324）

Roles of miR-494 in tumors

LI Ming-Chun, WU Ai-Bing, YANG Zhi-Xiong

  1. First Departerment of Oncology, Affiliated Hospital of Guangdong Medical College , Zhanjiang 524001, China

  • Online:2013-10-08Published:2013-09-23
  • Contact:YANG Zhi-xiong, E?-mail: yangzhixiong068@126.com E-mail:yangzhixiong068@126.com

PDF

1802

被引次数

4

摘要：miR-494参与正常细胞的细胞周期调控、分化和凋亡等过程。近年来研究表明，miR-494的异常表达与肿瘤的发生密切相关，其参与肿瘤细胞的侵袭和转移等过程。miR-494是一种肿瘤抑制基因，也可作为癌基因。其通过多种靶基因、信号通路对肿瘤发生发展进行调控。

关键词:微RNAs,肿瘤,靶基因

Abstract:MiR-494 involves in cell cycle regulation, differentiation and apoptosis processes of normal cells. Recent study shows that abnormal expression of miR-494 is associated with oncogenesis closely, and it participates in the invasion and metastasis of tumor cells and so on. MiR-494 is not only a tumor suppressor gene,but also can be considered as a cancer-promoting gene. MiR-494 can regulate the oncogenesis and development of the tumor through a variety of target genes and signaling pathways.

Key words:MicroRNAs,Neoplasms,Target gene