国际肿瘤学杂志››2013,Vol. 40››Issue (10): 748-751.

• 综述 •上一篇下一篇

减毒沙门菌在肿瘤基因治疗中应用

李鹏飞, 孙君重

  1. 100039北京,解放军总医院第一附属医院肿瘤科
  • 出版日期:2013-10-08发布日期:2013-09-23
  • 通讯作者:孙君重,E-mail:sjunzh07@163.com E-mail:sjunzh07@163.com
  • 基金资助:

    国家自然科学基金(81071839)

Application of attenuated salmonella in the gene treatment of tumor

LI Peng-Fei, SUN Jun-Zhong

  1. Department of Oncology, First Affiliated Hospital of General Hospital of PLA, Beijing 100039, China

  • Online:2013-10-08Published:2013-09-23
  • Contact:SUN Jun-zhong, E-mail: sjunzh07@163.com E-mail:sjunzh07@163.com

摘要:沙门菌是一类胞内侵袭性兼性厌氧菌,减毒后仍保留其抗原性,现在广泛作为DNA疫苗的载体。沙门菌携带相关抗原基因对多种肿瘤有显著的抑制效果,而且携带修复基因对放化疗后的机体损伤有着明确的修复作用

关键词:减毒沙门菌,肿瘤,疫苗载体,损伤修复

Abstract:Salmonella is a kind of intracellular invasive facultative anaerobe, maintaining its antigenicity after being attenuated. Now, it has been widely used as a transporter of DNA vaccines. Salmonella carrying related antigen gene can inhibit multiple tumors, and salmonella carrying repair gene has a clear repair effect for the organism injury after chemoradiotherapy.

Key words:Attenuated salmonella,Neoplasms,Vaccine carrier,Damage repairment