国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (3): 174-176.

• 综述 •上一篇下一篇

PRDM基因及DNA甲基化与肿瘤关系的研究进展

谭永丽, 谭双香, 胡瑞成

  1. 421001湖南衡阳南华大学研究生院（谭永丽）；湖南省老年医院湖南省老年医学研究所（谭双香、胡瑞成）

  • 出版日期:2013-03-08发布日期:2013-02-25
  • 通讯作者:胡瑞成 E-mail: E-mail:huruicheng@hotmail.com
  • 基金资助:

    湖南省自然科学基金项目（11JJ3110）

Advances of PRDM genes and DNA methylation in cancer

TAN Yong-Li, TAN Shuang-Xiang, HU Rui-Cheng

  1. TAN Yong-li＊, TAN Shuang-xiang, HU Rui-cheng.＊Postgraduate School, University of South China, Hengyang 421001, China

  • Online:2013-03-08Published:2013-02-25
  • Contact:HU Rui-cheng, E-mail: huruicheng@hotmail.com E-mail:huruicheng@hotmail.com

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摘要：PR结构域蛋白(PRDM)基因在细胞分化和增殖中发挥关键作用。该家族基因成员大多是抑癌基因，在多种肿瘤中异常表达参与肿瘤的发生。DNA异常甲基化常使这些基因沉默，可能发生在肿瘤早期，可以通过去甲基化使肿瘤发生逆转，为肿瘤的防治提供一条新的思路。

关键词:DNA甲基化,基因, 肿瘤抑制,肿瘤,PRDM基因

Abstract:PRDI-BF1 and RIZ homology domain containing proteins (PRDM) play a key role in cell differentiation and proliferation. Most members of the PRDM gene family are tumor suppressor genes which involved in tumorigenesis and abnormal expression in a variety of tumors. Aberrant DNA methylation often silences these genes, which may occur in the early stage of tumor. Cancer can be reversed by demethylation, which provides a new way for cancer treatment.

Key words:DNA methylation,Genes, tumor suppressor,Neoplasms,PRDM genes