国际肿瘤学杂志››2013,Vol. 40››Issue (3): 184-186.

• 综述 •上一篇下一篇

Bmi-1基因与放射抵抗的相关研究

熊蓓蓓,范华,李涛

  1. 646000泸州医学院附属医院肿瘤科(熊蓓蓓,范华);四川省肿瘤医院放疗科(李涛)
  • 出版日期:2013-03-08发布日期:2013-02-25
  • 通讯作者:李涛,E-mail: E-mail:litaoxmf@126.com
  • 基金资助:

    四川省2012年第一批科技计划项目(2012SZ0081)

Bmi-1 gene and radiation resistance

XIONG Bei-Bei, FAN Hua, LI Tao

  1. Department of Oncology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China
  • Online:2013-03-08Published:2013-02-25
  • Contact:LI Tao, E-mail: litaoxmf@126.com E-mail:litaoxmf@126.com

摘要:Bmi-1基因作为一种转录抑制因子,是多梳基因(polyeomb group gene)家族成员之一。可能在干细胞的自我更新与增殖活性起重要作用。目前发现Bmi-1基因在多种实体肿瘤中存在高表达,可看做为肿瘤干细胞标志物之一,并与肿瘤的发生发展及放射抵抗有密切关系,可为恶性肿瘤的治疗提供重要的靶基因。

关键词:肿瘤干细胞,放射疗法,Bmi-1基因

Abstract:As a transcriptional repressor, Bmi-1 is a member of polyeomb group gene family. It may play an important role in self-renewal ability and proliferation of stem cell. At present, studies show that Bmi-1is highly expressedin a variety of solid tumors, which can be regarded as one of the markers of cancer stem cells and has a close relation to the cancer development and progression and radiation resistance. It will provide an important target gene for the treatment of malignant tumors.

Key words:Neoplastic stem cells,Radiotherapy,Bmi-1 gene