国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (3): 212-214.

• 综述 •上一篇下一篇

Fas蛋白与非小细胞肺癌关系的研究进展

赵娜, 魏素菊

  1. 河北医科大学第四医院肿瘤诊疗中心肿瘤内科
  • 出版日期:2013-03-08发布日期:2013-02-25

FAS protein and non-small cell lung cancer

ZHAO Na, WEI Su-Ju

  1. Department of Medical Oncology, Fourth Hospital of Hebei Medical University , Shijiazhuang 050011, China

  • Online:2013-03-08Published:2013-02-25

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1475

被引次数

1

摘要：目前非小细胞肺癌（NSCLC）发生、发展及转移机制的研究不断深入，关于NSCLC中Fas及Fas配体（FasL）蛋白的表达以及其介导的凋亡、免疫逃逸在肺癌发生发展、转移及预后中的作用机制研究不断涌现。探讨Fas-FasL系统在NSCLC发生发展中所起的作用，可为临床早期诊断肺癌、判断预后、设计新的治疗策略提供依据。

关键词:癌, 非小细胞肺,细胞凋亡,肿瘤逃逸,Fas

Abstract:With the rapid growth of incidence of non-small cell lung cancer (NSCLC), more and more studies have been made about its occurrence, development and metastatic mechanism in recent years. Researches about Fas/FasL protein expression and Fas/FasL-mediated apoptosis, immune escape mechanism and their roles in the pathogenesis, progression and prognosis of lung cancer are constantly emerging. Discussion about the roles of Fas/ FasL system in NSCLC could provide evidence for early diagnosis, prognosis prediction and new treatment of NSCLC.

Key words:Carcinoma, non-small-cell lung,Apoptosis,Tumor escape,Fas