国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (4): 252-255.

• 综述 •上一篇下一篇

Vasohibin-1与肿瘤

赵广宁, 丁娜, 孙岩, 韩瑞发

  1. 天津医科大学第二医院泌尿外科，天津市泌尿外科研究所肿瘤分子遗传学研究室300211天津

  • 出版日期:2013-04-08发布日期:2013-03-27
  • 通讯作者:韩瑞发,E-mail：han_ruifa@hotmail.com E-mail:han_ruifa@hotmail.com

Vasohibin-1 and tumor

ZHAO Guang-Ning, DING Na, SUN Yan, HAN Rui-Fa

  1. Department of Urology, Second Hospital of Tianjin Medical University, Tumor Molecular Genetics Laboratory,Tianjin Institute of Urology, Tianjin 300211, China
  • Online:2013-04-08Published:2013-03-27
  • Contact:HAN Rui-fa E-mail:han_ruifa@hotmail.com

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被引次数

4

摘要：Vasohibin-1（VASH1)是新近发现的在血管内皮细胞中由血管内皮生长因子（VEGF）、成纤维生长因子-2（FGF-2）等诱导产生的具有负反馈调节血管生成作用的蛋白因子。近年来研究表明，Vasohibin-1在多种肿瘤血管生成中扮演着重要的角色，提示其有望成为相关肿瘤诊断和治疗的分子标志物以及分子靶向治疗的有效蛋白因子。

关键词:肿瘤,血管生成,Vasohibin-1

Abstract:Vasohibin-1(VASH1),which is induced in response to angiogenic stimuli such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF)-2, has recently been isolated as a novel negative feedback inhibitor of angiogenesis.Several studies have demonstrated that VASH1 plays important roles in the development of various tumors and it would potentially be a biomarker and a candidate for molecular targeted therapy for patients with cancer in the future.

Key words:Neoplasms,Angiogenesis,Vasohibin-1