国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (6): 425-428.

• 综述 •上一篇下一篇

PPARγ及上皮-间质转化与肿瘤的关系

高超, 冯向营

  1. 116021大连大学附属新华医院神经内一科
  • 出版日期:2013-06-08发布日期:2013-05-24
  • 通讯作者:冯向营，E-mail: daiyue315@126. com E-mail:daiyue315@126. com

Peroxisome proliferator-activated receptor gamma and epithelial-mesenchymal transition in cancer

GAO Chao, FENG Xiang-Ying

  1. Department of Neurology, Xinhua Hospital , Dalian University , Dalian 116021, China
  • Online:2013-06-08Published:2013-05-24
  • Contact:FENG Xiang-ying E-mail:daiyue315@126. com

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摘要：肿瘤发生上皮-间质转化（EMT）后侵袭和转移能力明显增强，是肿瘤患者治疗失败的原因之一。过氧化物酶增殖激活受体γ（PPARγ）是EMT的重要调节因子。研究提示PPARγ激活后，能通过调节E-钙黏蛋白、Smad复合体、机体微环境等影响肿瘤EMT的发生和发展。因此，深入研究PPARγ及EMT与肿瘤的关系有望为肿瘤治疗提供新的方向。

关键词:PPARγ,肿瘤,Smad 蛋白质类,E-钙黏蛋白

Abstract:Epithelial-mesenchymal transition (EMT) of cancer can enhance the abilities of invasion and metastasis of cancer cells, which is one of the reasons for treatment failure. Peroxisome proliferator-activated receptor gamma (PPARγ) is an important regulatory factor in EMT of cancer cells. Recent researches show that activation of PPARγ plays a role in the occurrence and development of EMT by regulating the E-cadherin, Smad complex and body microenvironment. Therefore, in-depth research for the relationship among PPARγ, EMT and cancer is expected to provide a new direction for tumor treatment.

Key words:PPAR gamma,Neoplasms,Smad protein,E-cadherin