国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (8): 643-645.

• 综述 •上一篇下一篇

血清胸苷激酶1与肿瘤

徐文静, 刘德干

  1. 225700江苏省兴化市人民医院肿瘤科
  • 出版日期:2013-09-08发布日期:2013-09-16
  • 通讯作者:徐文静，E-mail: 2007xuwenjing@163.com E-mail:2007xuwenjing@163.com

Serum thymidine kinase 1 and cancer

XU Wen-Jing, LIU De-Gan

  1. Department of Oncology, Xinghua People's Hospital of Jiangsu Province, Xinghua 225700, China
  • Online:2013-09-08Published:2013-09-16
  • Contact:Corresponding author: XU Wen-jing, E-mail: 2007xuwenjing@163.com E-mail:2007xuwenjing@163.com

PDF

2005

被引次数

2

摘要：胸苷激酶1(TK1)是一种嘧啶补救途径的激酶，能催化脱氧胸苷磷酸化为一腺胸苷酸，与细胞周期调控和细胞增殖密切相关。多项试验表明，TK1可用于健康体检、肿瘤筛查、常规检测、疗效监视和预后，是一种灵敏有效地评估人体肿瘤增长的标志物。

关键词:肿瘤,胸苷激酶,免疫组织化学

Abstract:Thymidine kinase 1 (TK1), an enzyme of the pyrimidine remedial pathway, can catalyze phosphorylation of thymidine to thymidine monophosphate. It is closely related to cell cycle regulation and cell proliferation. A number of experiments show that TK1 can be used for physical examination, tumor screening, routine testing, effect monitoring and prognosis, which is considered to be a sensitive and useful marker for human tumor growth.

Key words:Neoplasms,Thymidine kinase,Immunohistochemistry