国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (8): 662-665.

• 综述 •上一篇下一篇

鼻咽癌相关基因研究进展

程红蕾, 王若雨

  1. 116000大连大学附属中山医院肿瘤科

  • 出版日期:2013-09-08发布日期:2013-09-16
  • 通讯作者:王若雨，E-mail: wry1963@sohu.com E-mail:wry1963@sohu.com

Reserch progress of nasopharyngeal carcinoma related gene

CHENG Hong-Lei, WANG Ruo-Yu

  1. Department ofOncology, AffiliatedZhongshanHospitalof DalianUniversity,Dalian116000, China

  • Online:2013-09-08Published:2013-09-16
  • Contact:Corresponding author: WANG Ruo-yu, E-mail: wry1963@sohu.com E-mail:wry1963@sohu.com

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1740

被引次数

6

摘要：鼻咽癌的发生是一个多基因参与、多步骤的复杂过程，其中抑癌基因失活和癌基因活化是其发生的重要机制。与鼻咽癌有关的癌基因有Bcl-2、HGF、COX-2、LMP-1，抑癌基因有P53、P16、Nm23-H1、PTEN。随着基因研究的深入，除上述基因外，鼻咽癌还与PECAM-1、MMP-9、RECK等基因有关。这些基因在鼻咽癌的发生、发展过程中有重要作用并有可能成为鼻咽癌治疗的新靶点。

关键词:鼻咽肿瘤,基因

Abstract:The occurrence of nasopharyngeal carcinoma is a multi-gene, multi-step process. Among them, oncogene activation and antioncogene inactivation is the important mechanism. The related oncogenes of nasopharyngeal carcinoma contain Bcl-2, HGF, COX-2 and LMP-1. The related antioncogenes of nasopharyngeal carcinoma contain P53, P16, NM23-H1 and PTEN. With the deepening research on genes, studies also find that nasopharyngeal carcinoma is related to PECAM-1, MMP-9 and RECK. These genes play important roles in the occurrence and development of nasopharyngeal carcinoma, which may become new targets for the treatment of nasopharyngeal carcinoma.

Key words:Nasopharyngeal neoplasms,Genes