国际肿瘤学杂志››2014,Vol. 41››Issue (1): 11-13.doi:10.3760/cma.j.issn.1673-422X.2014.01.004

• 综述 •上一篇下一篇

假基因在肿瘤中的研究

曹林平, 吴健, 郑树森

  1. 310003杭州,浙江大学医学院附属第一医院肝胆外科,卫生部多器官联合移植研究重点实验室
  • 出版日期:2014-01-08发布日期:2014-01-22
  • 通讯作者:郑树森,E-mail:shusenzheng@zju.edu.cn E-mail:shusenzheng@zju.edu.cn
  • 基金资助:

    国家自然科学基金(81272281);浙江省自然科学基金杰出青年项目(R2110125)

Research progress of pseudogenes in tumor

CAO Lin-Ping, WU Jian, ZHENG Shu-Sen

  1. Dapartment of Hepatobiliary Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University; Key Laboratory of Combined Multiorgan Transplantation, Ministry of Public Health, Hangzhou 310003, China
  • Online:2014-01-08Published:2014-01-22
  • Contact:ZHENG Shu-Sen E-mail:shusenzheng@zju.edu.cn

摘要:假基因是指基因组中与正常编码蛋白基因序列相似,但缺乏明确生理功能的基因序列。近年来研究表明,许多假基因在肿瘤中能够活跃转录并翻译蛋白,在遗传水平、转录水平和转录后水平调控基因的表达活性,然而其功能及作用机制还有待进一步探索。

关键词:拟基因,肿瘤,微RNAs,RNA,小分子干扰

Abstract:Pseudogenes are sequences in the genome that are similar to the gene sequences which can encode proteins normally, but are lack of a clear physiological function. Recently, researches show that pseudogenes can transcribe and translate actively, and can regulate the expression of genes at the genetical, transcriptional and posttranscriptional levels. However, their effects and mechanisms remain to be clarified.

Key words:Pseudogenes,Neoplasms,MicroRNAs,RNA, small interfering