国际肿瘤学杂志

国际肿瘤学杂志››2014,Vol. 41››Issue (6): 422-424.

• 综述 •上一篇下一篇

慢病毒载体及其在肿瘤基因治疗中的研究应用

牛鑫, 邓志华

  1. 030001 太原，山西医科大学第二医院消化内科
  • 出版日期:2014-06-08发布日期:2014-05-08
  • 通讯作者:邓志华，Email:ykdzh@hotmail.com E-mail:ykdzh@hotmail.com
  • 基金资助:

    山西省自然科学基金（20120110386）

Progress of lentiviral vector on neoplasms gene therapy research

NIU Xin, DENG Zhi-Hua

  1. Department of Gastroenterology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Online:2014-06-08Published:2014-05-08
  • Contact:Deng Zhihua E-mail:ykdzh@hotmail.com

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被引次数

2

摘要：慢病毒载体（LV）是逆转录病毒载体中的特殊成员，已成为当前基因治疗载体研究的热点。研究表明LV可使目的基因稳定表达于肿瘤细胞，在消化系统、血液系统及妇科肿瘤等基因治疗中作为转运工具发挥了重要作用，为肿瘤基因治疗提供了新途径。

关键词:慢病毒属,肿瘤,基因疗法

Abstract:Lentiviral vectors (LV), a special member of retroviral vectors, has become hot in gene therapy research. Studies have shown that LV can make exogenous gene expressed stably in tumor cells. As a tool for transportation, LV plays a significant role in the gene therapy of digestive system, hematologic system and gynecological tumor, which provides a promising new way for neoplasms gene therapy.

Key words:Lentivirus,Neoplasms,Genetic therapy