转化生长因子-β与肿瘤

国际肿瘤学杂志››2015,Vol. 42››Issue (1): 43-45.doi:10.3760/cma.j.issn.1673-422X.2015.01.011

唐乃玲, 郭志, 杨雪玲

300060天津医科大学肿瘤医院介入治疗肿瘤科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室

收稿日期:2014-06-18修回日期:2014-08-04出版日期:2015-01-08发布日期:2015-01-07
通讯作者:郭志 E-mail:cjr.guozhi.@vip.163.com
基金资助:

天津市科技计划（12ZCDZSY17200）；中国博士后科学基金（2014M551032）；天津医科大学肿瘤医院博士启动基金（B1313）

Transforming growth factor-β and tumor

Tang Nailing, Guo Zhi, Yang Xueling

Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China

Received:2014-06-18Revised:2014-08-04Online:2015-01-08Published:2015-01-07
Contact:Guo Zhi E-mail:cjr.guozhi.@vip.163.com

摘要/Abstract

摘要：研究表明，转化生长因子β（TGFβ）在肿瘤初期通过抑制肿瘤细胞增殖、去分化以及促进细胞凋亡等发挥抑癌作用。但在肿瘤发展中，随着TGFβ通路相关分子发生变异以及TGFβ自身发生转变，其促癌作用逐步显现。TGFβ通路抑制剂具有抗肿瘤作用，但其临床疗效及不良反应仍有待观察。

唐乃玲, 郭志, 杨雪玲. 转化生长因子-β与肿瘤[J]. 国际肿瘤学杂志, 2015, 42(1): 43-45.

Tang Nailing, Guo Zhi, Yang Xueling. Transforming growth factor-β and tumor[J]. Journal of International Oncology, 2015, 42(1): 43-45.

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