国际肿瘤学杂志››2016,Vol. 43››Issue (2): 126-.

• 综述 •上一篇下一篇

盘状结构域受体2及其在肿瘤中的表达和作用

王雷, 刘东明

  1. 上海交通大学医学院附属仁济医院泌尿外科
  • 出版日期:2016-02-08发布日期:2015-12-28

Discoidin domain receptor 2 and its expression and role in tumor

WANG Lei, LIU Dong-Ming

  1. Department of Urology Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China
  • Online:2016-02-08Published:2015-12-28

摘要:盘状结构域受体2(DDR2)是一种受体酪氨酸激酶(RTK),可以被多种胶原(Ⅰ~Ⅲ、Ⅹ型)激活。近年来研究发现DDR2在人类多种肿瘤中呈差异性表达,提示其可能参与肿瘤的发生和发展过程,DDR2将来可能作为肿瘤基因治疗的一个潜在靶点。

关键词:胶原,肿瘤,盘状结构域受体2

Abstract:Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase (RTK) that can be activated by fibrillar collagens (ⅠⅢ , Ⅹ).Recently researchers show that the DDR2 is expressed differently in many cancers,which suggests DDR2 is probably correlated with tumorigenesis and cancer development,and it may become a promising cancer therapeutic target.

Key words:Collagen,Neoplasms,Discoidin domain receptor 2