国际肿瘤学杂志››2016,Vol. 43››Issue (5): 379-381.doi:10.3760/cma.j.issn.1673-422X.2016.05.015
田若楠,孙剑经,张林西
出版日期:
2016-05-08发布日期:
2016-04-07通讯作者:
张林西 E-mail:zlxwxl@163.com基金资助:
河北省自然科学基金(H2014405033)
Tian Ruonan,Sun Jianjing, Zhang Linxi
Online:
2016-05-08Published:
2016-04-07Contact:
Zhang Linxi E-mail:zlxwxl@163.com摘要:姜黄素可通过诱导细胞周期阻滞、阻断Notch信号通路来抑制食管癌细胞增殖,通过抑制核转录因子κB(NFκB)信号通路、抑制食管癌血管生成、抑制基质金属蛋白酶(MMP)来抑制食管癌细胞侵袭,通过核磷蛋白的表达与定位变化来调控食管癌细胞凋亡从而发挥抗食管癌作用。
田若楠,孙剑经,张林西. 姜黄素抗食管癌的机制[J]. 国际肿瘤学杂志, 2016, 43(5): 379-381.
Tian Ruonan,Sun Jianjing, Zhang Linxi. Mechanism of curcumin resisting esophageal cancer[J]. Journal of International Oncology, 2016, 43(5): 379-381.
[1] Liao S, Xia J, Chen Z, et al. Inhibitory effect of curcumin on oral carcinoma CAL27 cells via suppression of Notch1 and NFκB signaling pathways[J]. J Cell Biochem, 2011, 112(4): 1055-1065. DOI: 10.1002/jcb.23019. [2] Ashworth T, Roy AL. Phase specific functions of the transcription factor TFⅡⅠ during cell cycle[J]. Cell Cycle, 2009, 8(4): 596-605. [3] Mendelson J, Song S, Li Y, et al. Dysfunctional transforming growth factorβ signaling with constitutively active Notch signaling in Barrett′s esophageal adenocarcinoma[J]. Cancer, 2011, 117(16): 3691-3702. DOI: 10.1002/cncr.25861. [4] Peters JH, Avisar N. The molecular pathogenesis of Barrett′s esophagus: common signaling pathways in embryogenesis metaplasia and neoplasia[J]. J Gastrointest Surg, 2010, 14 Suppl 1: S81-87. DOI: 10.1007/s1160500910117. [5] Masuda S. Dysfunctional transforming growth factorβ signaling with constitutively active notch signaling in Barrett′s esophageal adenocarcinoma[J]. Cancer, 2012, 118(7): 1956-1957. DOI: 10.1002/cncr.26444. [6] Subramaniam D, Ponnurangam S, Ramamoorthy P, et al. Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling[J]. PLoS One, 2012, 7(2): e30590. DOI: 10.1371/journal.pone.0030590. [7] Tian F, Fan T, Zhang Y, et al. Curcumin potentiates the antitumor effects of 5FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NFκB signaling pathway in vitro and in vivo[J]. Acta BiochimBiophys Sin(Shanghai), 2012, 44(10): 847-855. [8] Hanahan D,Weinberg RA.Hallmarks of cancer: the next generation[J]. Cell, 2011, 144(5): 646-674. DOI: 10.1016/j.cell.2011.02.013. [9] Shehzad A, LeeJ, Lee YS. Curcumin in various cancers[J]. Biofactors, 2013, 39(1): 56-68. DOI: 10.1002/biof.1068. [10] Stasinopoulos I, Shah T, Penet MF, et al. Cox2 in cancer: Gordian knot or Achilles heel?[J]. Front Pharmacol, 2013, 4: 34. DOI: 10.3389/fphar.2013.00034. [11] Park J, Conteas CN. Anticarcinogenic properties of curcumin on colorectal cancer[J]. World J Gastrointe Oncol, 2010, 2(4): 169-176. DOI: 10.4251/wjgo.v2.i4.169. [12] Ye F, Zhang GH, Guan BX, et al. Suppression of esophageal cancer cell growth using curcumin, ()epigallocatechin3gallate and lovastatin[J]. World J Gastroenterol, 2012, 18(2): 126-135. DOI: 10.3748/wjg.v18.i2.126. [13] Xu XC. Risk factors and gene expression in esophageal cancer[J]. Methods Mol Biol, 2009, 471: 335-360. DOI: 10.1007/9781597454162_17. [14] Mukherjee T, Kumar A, Mathur M, et al. Ets1 and VEGF expression correlates with tumor angiogenesis, lymph node metastasis, and patient survival in esophageal squamous cell carcinoma[J]. J Cancer Res Clin Oncol, 2003, 129(7): 430-436. [15] Xiao X, Prasadan K, Guo P, et al.Pancreatic duct cells as a source of VEGF in mice[J]. Diabetologia, 2014, 57(5): 991-1000. DOI: 10.1007/s001250143179y. [16] Xiao X, Guo P, Chen Z, et al.Hypoglycemia reduces vascular endothelial growth factor a production by pancreatic beta cells as a regulator of beta cell mass[J]. J Biol Chem, 2013, 288(12): 8636-8646. DOI: 10.1074/jbc.M112.422949. [17] 武志, 潘晓玲, 仲洁. MMP2和MMP9在食管癌中表达的研究[J]. 国际肿瘤学杂志, 2013, 40(9): 708-711. DOI: 10.3760/cma.j.issn.1673422X.2013.09.022. [18] Chen Y, Jiang T, Mao A, et al. Esophageal cancer stem cells express PLGF to increasecancer invasion through MMP9 activation[J]. Tumor Biol, 2014, 35(12): 12749-12755. DOI: 10.1007/s132770142601x. [19] Colombo E, Alcalay M, Pelicci PG. Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases[J]. Oncogene, 2011, 30(23): 2595-2609. DOI: 10.1038/onc.2010.646. [20] Chiarella S, De Cola A, Scaglione GL, et al. Nucleophosmin mutations alter its nucleolar localization by impairing Gquadruplex binding at ribosomal DNA[J]. Nucleic Acids Res, 2013, 41(5): 3228-3239. DOI: 10.1093/nar/gkt001. [21] Shi SL, Liang Y, Li QF, et al. Localization of nucleophosmin in nuclear matrix and changes in its expression during the differentiation of human neuroblastoma induced by retinoic acid[J]. J Cell Biochem, 2010, 111(1): 67-74. DOI: 10.1002/jcb.22663. [22] Weng CH, Yung BY, Weng JJ, et al. Involvement of nucleophosmin/B23 in the cellular response to curcumin[J]. J Nutr Biochem, 2011, 22(1): 46-52. DOI: 10.1016/j.jnutbio.2009.11.010. |
[1] | 杨蜜, 别俊, 张加勇, 邓佳秀, 唐组阁, 卢俊.局部晚期可切除食管癌新辅助治疗疗效及预后分析[J]. 国际肿瘤学杂志, 2024, 51(6): 332-337. |
[2] | 刘静, 刘芹, 黄梅.基于SMOTE算法的食管癌放化疗患者肺部感染的预后模型构建[J]. 国际肿瘤学杂志, 2024, 51(5): 267-273. |
[3] | 万芳, 杨钢, 李睿, 万启晶.食管癌患者血清miR-497、miR-383水平及临床意义[J]. 国际肿瘤学杂志, 2024, 51(4): 204-209. |
[4] | 中国医师协会放射肿瘤治疗医师分会, 中华医学会放射肿瘤治疗学分会, 中国抗癌协会肿瘤放射治疗专业委员会.中国食管癌放射治疗指南(2023年版)[J]. 国际肿瘤学杂志, 2024, 51(1): 1-20. |
[5] | 高新雨, 李振江, 孙洪福, 韩丹, 赵倩, 刘成新, 黄伟.基于MR加速器的MR引导放疗在食管癌患者中的临床应用[J]. 国际肿瘤学杂志, 2024, 51(1): 37-42. |
[6] | 山东省医学会肺癌食管癌多学科联合委员会.山东省医学会食管癌多学科规范化诊疗指南(2023年版)[J]. 国际肿瘤学杂志, 2023, 50(7): 385-397. |
[7] | 冀世玉, 张明鑫, 谢华红, 白渊, 王彤.不同支架治疗晚期食管癌患者的疗效观察[J]. 国际肿瘤学杂志, 2023, 50(2): 76-81. |
[8] | 巩合义, 伊艳, 张健, 李宝生.局部晚期可手术食管癌经新辅助放化疗达临床完全缓解后的处理策略[J]. 国际肿瘤学杂志, 2023, 50(12): 745-750. |
[9] | 吴浦嫄, 祁亮, 王涛, 史敏科, 孙雨薇, 王立峰, 刘宝瑞, 闫婧, 任伟.基于高频复发区改良临床靶区的术后放疗在食管鳞状细胞癌中的疗效研究[J]. 国际肿瘤学杂志, 2022, 49(8): 464-472. |
[10] | 戴李宸, 胡莉钧, 于静萍.尼妥珠单抗治疗食管鳞状细胞癌的应用进展[J]. 国际肿瘤学杂志, 2022, 49(8): 484-489. |
[11] | 夏玲玲, 陈永顺, 李彬, 宁婷婷, 张蔡羽天.pN+食管鳞状细胞癌患者R0切除术后放化疗与化疗的安全性及有效性比较[J]. 国际肿瘤学杂志, 2022, 49(6): 334-339. |
[12] | 叶倩, 凌志, 刘申香, 路国涛, 殷旭东.肌肉减少症对老年食管癌患者根治性放疗临床疗效及预后的影响[J]. 国际肿瘤学杂志, 2022, 49(4): 199-205. |
[13] | 周剑烽, 王铁君.食管癌的靶向治疗及免疫治疗[J]. 国际肿瘤学杂志, 2022, 49(4): 237-242. |
[14] | 刘佳, 葛小林, 狄晓珂, 史玉静, 曾玉婷.喜炎平注射液预防放射性食管炎的疗效分析[J]. 国际肿瘤学杂志, 2022, 49(3): 146-150. |
[15] | 张俊鹏, 于燕燕, 李宝生.lncRNA、circRNA调控食管鳞状细胞癌放化疗敏感性的作用机制[J]. 国际肿瘤学杂志, 2022, 49(3): 185-189. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||