染料木素在恶性肿瘤发生发展中的作用机制

国际肿瘤学杂志››2016,Vol. 43››Issue (8): 609-611.doi:10.3760/cma.j.issn.1673-422X.2016.08.011

染料木素在恶性肿瘤发生发展中的作用机制

熊婷,李丽丁,严欣,谢飞燕,廖彩勤 ,陆凯强,刘晓旺,涂剑

421001衡阳，南华大学药物药理研究所

出版日期:2016-08-08发布日期:2016-07-05
通讯作者:涂剑，Email: tujian0734@aliyun.com E-mail:tujian0734@aliyun.com
基金资助:

国家自然科学基金（81541163）；湖南省自然科学基金（2015JJ3101）；湖南省教育厅创新平台开放基金（15K111）； “湖南省分子靶标新药研究协同创新中心”培育项目（2014-405）；南华大学分子靶标新药协同创新中心研究生创新项目（D223-0002-00028）

The mechanism of Genistein in the genesis and development of malignant tumor

Xiong Ting, Li Liding, Yan Xin, Xie Feiyan, Liao Caiqin, Lu Kaiqiang, Liu Xiaowang, Tu Jian

Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China

Online:2016-08-08Published:2016-07-05
Contact:Tu Jian, Email: tujian0734@aliyun.com E-mail:tujian0734@aliyun.com
Supported by:

National Natural Science Foundation of China (81541163); Natural Science Foundation of Hunan Province of China (2015JJ3101); Open Fund Based on Innovation Platform of Hunan Provincial Education Department (15K111); Hunan Provincial Cooperative Innovation Center for Molecular Target New Drug Study (2014-405); Innovation Program of Graduate Education in Cooperative Innovation Center for Molecular Target New Drug of University of South China (D223-0002-00028)

摘要/Abstract

摘要：作为一种大豆活性提取物和天然的酪氨酸激酶抑制剂，染料木素与多种恶性肿瘤如乳腺癌、卵巢癌和前列腺癌等的发生发展密切相关。体内外研究表明染料木素能通过与雌激素受体结合抑制癌细胞增殖、侵袭转移，诱导凋亡和抗血管新生，从而发挥抗癌作用，提示染料木素可能成为今后临床治疗肿瘤的一种新药。

关键词:肿瘤,药理作用分子作用机制,染料木素

Abstract:Genistein, as a kind of natural inhibitor of tyrosinespecific protein kinases from soybean extracts, has been proved to be closely related to the development of various malignancy tumors such as breast cancer, ovarian cancer and prostate cancer. Studies in vivo and in vitro have indicated that Genistein can inhibit tumor proliferation, invasion and metastasis, induce apoptosis and has the function of antiangiogenesis by combining with estrogen receptor in order to play anticancer effect, which suggest that Genistein may become a new drug in clinical treatment of tumor in the future.

Key words:Neoplasms,Molecular mechanisms of pharmacological action,Genistein

熊婷,李丽丁,严欣,谢飞燕,廖彩勤 ,陆凯强,刘晓旺,涂剑. 染料木素在恶性肿瘤发生发展中的作用机制[J]. 国际肿瘤学杂志, 2016, 43(8): 609-611.

Xiong Ting, Li Liding, Yan Xin, Xie Feiyan, Liao Caiqin, Lu Kaiqiang, Liu Xiaowang, Tu Jian. The mechanism of Genistein in the genesis and development of malignant tumor[J]. Journal of International Oncology, 2016, 43(8): 609-611.

参考文献

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