碱基切除修复及其靶向治疗策略

摘要/Abstract

摘要：碱基切除修复（BER）是DNA氧化损伤修复的重要通路，该通路的突变造成基因不稳定而增加癌症风险。大量研究已证明，BER通路的关键蛋白，如DNA糖基化酶、脱嘌呤/嘧啶核酸内切酶1、DNA聚合酶等，在多种肿瘤中异常表达。此外这些蛋白的单核苷酸多态性影响肿瘤细胞的修复活性，有望成为肿瘤诊断、治疗及预后评估的重要指标。

张天棋，王红兵. 碱基切除修复及其靶向治疗策略[J]. 国际肿瘤学杂志, 2017, 44(11): 856-859.

张天棋，王红兵. Base excision repair and targeted therapy strategies[J]. Journal of International Oncology, 2017, 44(11): 856-859.

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碱基切除修复及其靶向治疗策略

Base excision repair and targeted therapy strategies

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