前列腺素E2对肿瘤微环境中髓源性抑制细胞的调控作用

摘要/Abstract

摘要：髓源性抑制细胞（MDSC）是一群未成熟的骨髓异质性细胞，在肿瘤免疫耐受和免疫抑制中具有重要作用。近年越来越多的研究结果表明前列腺素E2（PGE2）与MDSC有着密不可分的关系，PGE2在肿瘤微环境中通过作用其相关受体，调控信号转导与转录激活因子3（STAT3）和蛋白激酶A等细胞信号通路及细胞因子的分泌，影响着MDSC的增殖、分化及功能。

谢辉兰,张民皓,顾连兵,鲍红光. 前列腺素E2对肿瘤微环境中髓源性抑制细胞的调控作用[J]. 国际肿瘤学杂志, 2017, 44(3): 182-185.

Xie Huilan, Zhang Minhao, Gu Lianbing, Bao Hongguang. Regulation of myeloidderived suppressor cells by prostaglandin E2 in tumor microenvironment[J]. Journal of International Oncology, 2017, 44(3): 182-185.

参考文献

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