国际肿瘤学杂志››2017,Vol. 44››Issue (8): 619-621.doi:10.3760/cma.j.issn.1673-422X.2017.08.016

• 综述 •上一篇下一篇

MTHFR基因多态性与结直肠癌的相关性

张惠博,杨琰英,宋启斌

  1. 430060 武汉大学人民医院肿瘤中心(张惠博、宋启斌);武汉大学第一临床学院(杨琰英)
  • 出版日期:2017-08-08发布日期:2017-07-21
  • 通讯作者:宋启斌,Email: qibinsong@163.com E-mail:qibinsong@163.com
  • 基金资助:

    国家自然科学基金(81372407)

Association between MTHFR polymorphisms and colorectal cancer

Zhang Huibo, Yang yanying, Song Qibin

  1. Cancer Center, People′s Hospital of Wuhan University, Wuhan 430060, China
  • Online:2017-08-08Published:2017-07-21
  • Contact:Song Qibin, Email: qibinsong@163.com E-mail:qibinsong@163.com
  • Supported by:

    National Natural Science Foundation of China (81372407)

摘要:结直肠癌是全球最常见的恶性肿瘤之一。亚甲基四氢叶酸还原酶(MTHFR)是叶酸代谢的关键酶,近年来许多研究显示其基因多态性与结直肠癌的发病率、相关抗肿瘤药物的疗效及预后相关,但结论尚不完全一致,有待更多临床研究证实。

关键词:多态性,单核苷酸,结直肠肿瘤,亚甲基四氢叶酸还原酶

Abstract:Colorectal cancer (CRC) is one of the most common malignancies in the world. Methylene tetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolism process. In recent years, many studies indicate that MTHFR polymorphisms are significantly associated with the morbidity, response to chemotherapy and prognosis of CRC, but conclusions are inconsistent and remain to be further confirmed.

Key words:Polymorphism, single nucleotide,Colorectal neoplasms,Methylene tetrahydrofolate reductase