循环肿瘤细胞在临床应用中的研究进展

摘要/Abstract

摘要：循环肿瘤细胞（CTC）是从原发肿瘤或转移瘤脱落进入血液循环的肿瘤细胞。CTC目前被美国食品药品管理局（FDA）批准的临床适应证是可作为转移性乳腺癌、转移性前列腺癌和转移性结直肠癌患者的预后标志物。CTC在其他转移性或局限性肿瘤的预后评估，以及在肿瘤的早期筛查、分子表达谱的分析、治疗方案的制定及治疗效果的监测等方面也具有巨大的潜力。目前各项研究正在开展以深入挖掘CTC的临床应用潜力，为肿瘤患者的个体化精准治疗提供新策略和新前景。

关键词:肿瘤循环细胞,诊断,预后,液体活检

Abstract:Circulating tumor cells (CTCs) are cancerous cells that shed from the primary tumor or metastases into the bloodstream. The currently clinical applicability of CTCs approved by the US Food and Drug Administration (FDA) is that CTCs can be prognostic biomarker for patients with metastatic breast cancer, prostate cancer and colorectal cancer. CTCs also have great potential in the prognosis assessment of other metastatic or localized tumors, as well as early screening of tumors, analysis of molecular profiling, guiding treatment decisions, and monitoring of treatment response. Currently, various studies are being carried out to further explore the clinical application of CTCs, and provide new strategies and new prospects for individualized and precise treatment of cancer patients.

Key words:Neoplasm circulating cells,Diagnosis,Prognosis,Liquid biopsy

陈罗军，李娜，田景媛，宋启斌，于金明. 循环肿瘤细胞在临床应用中的研究进展[J]. 国际肿瘤学杂志, 2018, 45(8): 552-555.

Chen Luojun, Li Na, Tian Jingyuan, Song Qibin, Yu Jinming. Progress of circulating tumor cells in clinical application[J]. Journal of International Oncology, 2018, 45(8): 552-555.

参考文献

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