同源盒基因MEOX1在肿瘤中的研究进展

国际肿瘤学杂志››2019,Vol. 46››Issue (5): 278-280.doi:10.3760/cma.j.issn.1673-422X.2019.05.005

同源盒基因MEOX1在肿瘤中的研究进展

张媛，孙力超

国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室，北京100021

收稿日期:2019-04-16出版日期:2019-05-08发布日期:2019-06-14
通讯作者:孙力超 E-mail:sunlichao@cicams.ac.cn
基金资助:

国家自然科学基金（81773170）；中国医学科学院医学与健康科技创新工程（2016-I2M-3-013）

Advances of homeobox gene MEOX1 in tumors

Zhang Yuan, Sun Lichao

National Cancer Center, National Clinical Research Center for Cancer; State Key Laboratory of Molecular Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Received:2019-04-16Online:2019-05-08Published:2019-06-14
Contact:Sun Lichao E-mail:sunlichao@cicams.ac.cn
Supported by:

National Natural Science Foundation of China (81773170); Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2016-I2M-3-013)

摘要/Abstract

摘要：作为一种同源盒转录因子，MEOX1可通过与基因组特异DNA基序相结合调控目的基因的表达。MEOX1在细胞增殖、迁移和分化中起关键作用，并参与胚胎发育中骨骼、肌肉、血管的形成。近年来研究发现，MEOX1在乳腺癌、肺癌、卵巢癌、前列腺癌等多种肿瘤组织中高表达，并与肿瘤患者的淋巴结转移和不良预后密切相关。同时MEOX1还可调控肿瘤细胞的增殖和迁移，提示其在肿瘤的发生发展中起重要作用。

关键词:基因,同源盒,肿瘤,MEOX1

Abstract:As a homeobox transcription factor, MEOX1 can regulate the target genes by binding the specific DNA sequence. MEOX1 not only plays essential roles in cell proliferation, migration and differentiation, but also participates in the formation of skeleton, muscle and blood vessel during embryonic development. Recent studies demonstrate that MEOX1 is over-expressed in breast cancer, lung cancer, ovarian cancer and prostate cancer tissues, which is closely associated with lymph node metastasis and poor prognosis in patients with cancer. Furthermore, MEOX1 can regulate the proliferation and migration of cancer cells, which suggests that it plays an important role in the occurrence and development of tumors.

Key words:Genes, homeobox,Neoplasms,MEOX1

张媛，孙力超. 同源盒基因MEOX1在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2019, 46(5): 278-280.

Zhang Yuan, Sun Lichao. Advances of homeobox gene MEOX1 in tumors[J]. Journal of International Oncology, 2019, 46(5): 278-280.

参考文献

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