泛素特异性蛋白酶对肿瘤放疗敏感性的影响

摘要/Abstract

摘要：泛素特异性蛋白酶是去泛素化酶家族中的一员，能逆转蛋白质的泛素化降解，从而达到稳定蛋白质的目的。其通过调控肿瘤细胞的DNA损伤、细胞周期、核转录因子κB信号通路、Nrf2Keap1信号通路、癌基因cmyc等，影响肿瘤对放疗的敏感性，有望成为肿瘤放疗增敏的新靶点。

周奇芬，吴春林. 泛素特异性蛋白酶对肿瘤放疗敏感性的影响[J]. 国际肿瘤学杂志, 2019, 46(7): 420-422.

Zhou Qifen, Wu Chunlin. Effect of ubiquitin-specific protease on radiosensitivity of tumor[J]. Journal of International Oncology, 2019, 46(7): 420-422.

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泛素特异性蛋白酶对肿瘤放疗敏感性的影响

Effect of ubiquitin-specific protease on radiosensitivity of tumor

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