基于FIT与肠道菌群的结直肠癌风险评估模型的研究进展

摘要/Abstract

摘要：

结直肠癌风险评估模型是结直肠癌筛查工作中甄别结直肠癌高危人群的重要方法。近年来，粪便免疫化学试验（FIT）和肠道菌群成为研究的热点，国内外学者在FIT和肠道菌群的基础上建立了多种结直肠癌风险评估模型，其中包括基于FIT的结直肠癌风险评估模型、基于肠道菌群的结直肠癌风险评估模型、基于FIT和肠道菌群的结直肠癌风险评估模型，上述评估模型均有助于结直肠癌筛查与早诊早治。在现有的评估模型中，基于FIT和肠道菌群的评估模型对结直肠癌展现出较高的诊断效能，有望成为具有价值的非侵入性结直肠癌筛查方式。

关键词:结直肠肿瘤,粪便,潜血,胃肠道微生物组,危险性评估

Abstract:

Colorectal cancer risk assessment model is an important method to identify high-risk groups of colorectal cancer in colorectal cancer screening. In recent years， fecal immunochemical test （FIT） and gut microbiota have become research hotspots. Domestic and foreign scholars have established a variety of colorectal cancer risk assessment models based on FIT and gut microbiota， including colorectal cancer risk assessment models based on FIT， colorectal cancer risk assessment models based on gut microbiota， and colorectal cancer risk assessment models based on FIT and gut microbiota. The above assessment models are helpful for colorectal cancer screening and early diagnosis and treatment. Among the existing assessment models， the FIT combined with gut microbiota assessment model has shown a high diagnostic efficiency for colorectal cancer， which is expected to become a valuable non-invasive screening method for colorectal cancer.

Key words:Colorectal neoplasms,Feces,Occult blood,Gastrointestinal microbiome,Risk assessment

张蕊, 褚衍六. 基于FIT与肠道菌群的结直肠癌风险评估模型的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 370-375.

Zhang Rui, Chu Yanliu. Research progress of colorectal cancer risk assessment models based on FIT and gut microbiota[J]. Journal of International Oncology, 2024, 51(6): 370-375.

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