M2型巨噬细胞标志物CD206与肿瘤

摘要/Abstract

摘要：肿瘤相关巨噬细胞存在于肿瘤进展的所有阶段，起到促进血管生成、组织侵袭等作用，其中以M2型巨噬细胞居多。CD206是M2型巨噬细胞标志物，具有高度特异性，与肿瘤细胞的增殖和转移密不可分。已有研究表明CD206与乳腺癌、卵巢癌、胰腺癌、前列腺癌等恶性肿瘤密切相关，深化对CD206的研究对阐述肿瘤免疫微环境的形成机制、寻找更具针对性的靶向药物有一定的临床指导意义。

李悦，高磊，李红昌，于宏杰，张勇. M2型巨噬细胞标志物CD206与肿瘤[J]. 国际肿瘤学杂志, 2019, 46(3): 174-177.

Li Yue, Gao Lei, Li Hongchang, Yu Hongjie, Zhang Yong. M2 macrophage marker CD206 and tumor[J]. Journal of International Oncology, 2019, 46(3): 174-177.

［1］ Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］. CA Cancer J Clin, 2018, 68(6): 394424. DOI: 10.3322/caac.21492. ［2］陈万青, 郑荣寿, 张思维. 中国恶性肿瘤的动态变化［J］. 科技导报, 2014, 32(26): 6571. DOI: 10.3981/j.issn.10007857.2014.26.009. ［3］魏智民, 孙玉发, 李刚, 等. 癌症相关性炎症与肿瘤微环境相关研究进展［J］. 中国肿瘤临床, 2018, 45(21): 11171121. DOI: 10.3969/j.issn.10008179.2018.21.767. ［4］李悦, 徐可, 韩增祥, 等. 结肠癌中肿瘤相关巨噬细胞的作用及靶向治疗的研究进展［J］. 实用肿瘤学杂志, 2018, 32(5): 450454. DOI: 10.11904/j.issn.10023070.2018.05.013. ［5］ Guo Q, Jin Z, Yuan Y, et al. New mechanisms of tumorassociated macrophages on promoting tumor progression: recent research advances and potential targets for tumor immunotherapy［J］. J Immunol Res, 2016, 2016: 9720912. DOI: 10.1155/2016/9720912. ［6］ Yang Y, Cheng S, Liang G, et al. Celastrol inhibits cancer metastasis by suppressing M2like polarization of macrophages［J］. Biochem Biophys Res Commun, 2018, 503(2): 414419. DOI: 10.1016/j.bbrc.2018.03.224. ［7］ Suzuki Y, Shirai M, Asada K, et al. Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis［J］. Sci Rep, 2018, 8(1): 13129. DOI: 10.1038/s41598018315655. ［8］ Hu Z, Shi X, Yu B, et al. Structural insights into the pHdependent conformational change and collagen recognition of the human mannose receptor［J］. Structure, 2018, 26(1): 6071. DOI: 10.1016/j.str.2017.11.006. ［9］ Azad AK, Rajaram MV, Schlesinger LS. Exploitation of the macrophage mannose receptor (CD206) in infectious disease diagnostics and terapeutics［J］. J Cytol Mol Biol, 2014, 1(1): pii: 1000003. DOI: 10.13188/23254653.1000003. ［10］ Dong P, Ma L, Liu L, et al. CD86+/CD206+, diametrically polarized tumorassociated macrophages, predict hepatocellular carcinoma patient prognosis［J］. Int J Mol Sci, 2016, 17(3): 320. DOI: 10.3390/ijms17030320. ［11］ KoruSengui T, Santander AM, Miao F, et al. Breast cancers from black women exhibit higher numbers of immunosuppressive macrophages with proliferative activity and of crownlike structures associated with lower survival compared to nonblack Latinas and Caucasians［J］. Breast Cancer Res Treat, 2016, 158(1): 113126. DOI: 10.1007/s1054901638473. ［12］ Azad AK, Rajaram MV, Metz WL, et al. γTilmanocept, a new radiopharmaceutical tracer for cancer sentinel lymph nodes, binds to the mannose receptor (CD206)［J］. J Immunol, 2015, 195(5): 20192029. DOI: 10.4049/jimmunol.1402005. ［13］ Qiu SQ, Waaijer SJH, Zwager MC, et al. Tumorassociated macrophages in breast cancer: innocent bystander or important player［J］. Cancer Treat Rev, 2018, 70: 178179. DOI: 10.1016/j.ctrv.2018.08.010. ［14］ Zhao X, Qu J, Sun Y, et al. Prognostic significance of tumorassociated macrophages in breast cancer: a metaanalysis of the literature［J］. Oncotarget, 2017, 8(18): 3057630586. DOI: 10.18632/oncotarget.15736. ［15］ Xu X, Ye J, Huang C, et al. M2 macrophagederived IL6 mediates resistance of breast cancer cells to hedgehog inhibition［J］. Toxicol Appl Pharmacol, 2019, 1(364): 7782. DOI: 10.1016/j.taap.2018.12.013. ［16］ Fusser M, verbye A, Pandya AD, et al. Cabazitaxelloaded poly (2ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft［J］. J Control Release, 2019, 293: 183192. DOI: 10.1016/j.jconrel.2018.11.029. ［17］ Webb PM, Jordan SJ. Epidemiology of epithelial ovarian cancer［J］. Best Pract Res Clin Obstet Gynaecol, 2017, 41: 314. DOI: 10.1016/j.bpobgyn.2016.08.006. ［18］ Gupta KK, Gupta VK, Naumann RW. Ovarian cancer: screening and future directions［J］. Int J Gynecol Cancer, 2019, 29(1): 195200. DOI: 10.1136/ijgc2018000016. ［19］ Stewart C, Ralyea C, Lockwood S. Ovarian cancer: an integrated review［J］. Semin Oncol Nurs, 2019, (19): 3001230019. DOI: 10.1016/j.soncn.2019.02.001. ［20］ Jing X, Peng J, Dou Y, et al. Macrophage ERα promoted invasion of endometrial cancer cell by mTOR/KIF5Bmediated epithelial to mesenchymal transition［J］. Immunol Cell Biol, 2019, In press. DOI: 10.1111/imcb.12245. ［21］ Chen X, Zhou J, Li X, et al. Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumorpromoted phenotype［J］. Cancer Lett, 2018, 435: 8091. DOI: 10.1016/j.canlet.2018.08.001. ［22］ Neelakantan D, Dogra S, Devapatla BR, et al. Multifunctional APJ pathway promotes ovarian cancer progression and metastasis［J］. Mol Cancer Res, 2019, In press. DOI: 10.1158/15417786.MCR180989. ［23］ Ko SY, Ladanyi A, Lengyel E, et al. Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumorpromoting phenotype［J］. Am J Pathol, 2014, 184(1): 271281. DOI: 10.1016/j.ajpath.2013.09.017. ［24］ Rahib L, Smith BD, Aizenberg R, et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States［J］. Cancer Res, 2014, 74(11): 29132921. DOI: 10.1158/00085472.CAN140155. ［25］ Sun H, Ma H, Hong G, et al. Survival improvement in patients with pancreatic cancer by decade: a period analysis of the SEER database, 19812010［J］. Sci Rep, 2014, 4: 6747. DOI: 10.1038/srep06747. ［26］ Wang W, Marinis JM, Beal AM, et al. RIP1 kinase drives macrophagemediated adaptive immune tolerance in pancreatic cancer［J］. Cancer Cell, 2018, 34(5): 757774. DOI: 10.1016/j.ccell.2018.10.006. ［27］ Rouven LK, Eric F, Christine H, et al. A myeloid and lymphoid infltrate in murine pancreatic tumors exposed to plasmatreated medium［J］. Clin Plasma Med, 2018, 11: 1017. DOI: 10.1016/j.cpme.2018.07.001. ［28］ Wang B, Zheng X, Liu J, et al. Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumorinfiltrating M2 macrophages［J］. J Pharmacol Sci, 2018, 137(3): 290298. DOI: 10.1016/j.jphs.2018.07.007. ［29］ Zarif JC, Yang W, Hernandez JR, et al. The identification of macrophageenriched glycoproteins using glycoproteomics［J］. Mol Cell Proteomics, 2017, 16(6): 10291037. DOI: 10.1074/mcp.M116.064444. ［30］ Zarif JC, Valle JB, Hicks JL, et al. Mannose receptorpositive macrophage infiltration correlates with prostate cancer onset and metastatic castrationresistant disease［J］. Eur Urol Oncol, 2018, In press. DOI: 10.1016/j.euo.2018.09.014. ［31］ SolísMartínez R, CancinoMarentes M, HernándezFlores G, et al. Regulation of immunophenotype modulation of monocytesmacrophages from M1 into M2 by prostate cancer cellculture supernatant via transcription factor STAT3［J］. Immunol Lett, 2018, 196: 140148. DOI: 10.1016/j.imlet.2018.02.009. ［32］ Jones JD, Sinder BP, Paige D, et al. Trabectedin reduces skeletal prostate cancer tumor size in association with effects on M2 macrophages and efferocytosis［J］. Neoplasia, 2019, 21(2): 172184. DOI: 10.1016/j.neo.2018.11.003. ［33］ Yao Z, Zhang J, Zhang B, et al. Imatinib prevents lung cancer metastasis by inhibiting M2like polarization of macrophages［J］. Pharmacol Res, 2018, 133: 121131. DOI: 10.1016/j.phrs.2018.05.002. ［34］ Smolarczyk R, Cichoń T, Pilny E, et al. Combination of antivascular agentDMXAA and HIF1α inhibitordigoxin inhibits the growth of melanoma tumors［J］. Sci Rep, 2018, 8(1): 7355. DOI: 10.1038/s4159801825688y. ［35］ Ding P, Wang W, Wang J, et al. Expression of tumorassociated macrophage in progression of human glioma［J］. Cell Biochem Biophys, 2014, 70(3): 16251631. DOI: 10.1007/s1201301401053. ［36］ Lin X, Wang S, Sun M, et al. miR1955p/NOTCH2mediated EMT modulates IL4 secretion in colorectal cancer to affect M2like TAM polarization［J］. J Hematol Oncol, 2019, 12(1): 20. DOI: 10.1186/s1304501907087. ［37］ Kovaleva OV， Samoilova DV， Shitova MS, et al. Tumor associated macrophages in kidney cancer［J］. Anal Cell Pathol (Amst), 2016: 9307549. DOI: 10.1155/2016/9307549. ［38］ Liu H, Dong H, Jiang L, et al. Bleomycin inhibits proliferation and induces apoptosis in TPC1 cells through reversing M2macrophages polarization［J］. Oncol Lett, 2018, 16(3): 38583866. DOI: 10.3892/ol.2018.9103. ［39］ Andersen MN, Andersen NF, RodgaardHansen S, et al. The novel biomarker of alternative macrophage activation, soluble mannose receptor (sMR/sCD206): implications in multiple myeloma［J］. Leuk Res, 2015, 39(9): 971975. DOI: 10.1016/j.leukres.2015.06.003. ［40］ Josephs DH, Bax HJ, Karagiannis SN. Tumourassociated macrophage polarisation and reeducation with immunotherapy［J］. Front Biosci (Elite Ed), 2015, 7: 293308. ［41］ Hodgkinson N, Kruger C, Abrahamse H. Targeted photodynamic therapy as potential treatment modality for the eradication of colon cancer and colon cancer stem cells［J］. Tumour Biol, 2017, 39(10): 1010428317734691. DOI: 10.1177/1010428317734691.

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M2 macrophage marker CD206 and tumor

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