国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (2): 108-110.

• 综述 •上一篇下一篇

缺氧导致肿瘤发生的机制

张百红

  1. 730050 兰州军区兰州总医院肿瘤科
  • 出版日期:2012-02-08发布日期:2012-01-18

Mechanisms of hypoxia triggering tumor development

ZHANG Bai-Hong

  1. Department of Oncology, General Hospital of Lanzhou Military Region, Lanzhou 730050, China
  • Online:2012-02-08Published:2012-01-18

PDF

2895

被引次数

9

摘要：高海拔地区的缺氧对肿瘤的发生和发展密切相关。缺氧通过多种机制促进肿瘤的发生发展，包括诱发酸性内环境、触发肿瘤微血管形成、影响血管生成拟态、诱导上皮间质转化、重塑细胞外基质、促进肿瘤免疫逃避和肿瘤适应、维持肿瘤干细胞的存在以及抑制衰老。靶向缺氧可能成为肿瘤治疗新的有效策略。

关键词:肿瘤,缺氧

Abstract:High-altitude hypoxia is closely associated with cancer initiation and progression. Hypoxia promotes tumor development through multiple mechanisms including modifying acidic microenvironment, triggering tumor angiogenesis, influencing vasculogenic mimicry, inducing epithelial-mesenchymal transition, remodeling of extracellular matrix, promoting immune escape and adaptive landscapes, maintaining cancer stem cells and inhibiting senescence. Targeting hypoxia may become a novel efficient strategy for cancer therapy.

Key words:font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt">Neoplasmsfont-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt,mso-bidi-font-size: 10.5pt">,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体">Anoxia