国际肿瘤学杂志››2012,Vol. 39››Issue (6): 415-417.

• 综述 •上一篇下一篇

肝再生磷酸酶-3及其抑制剂在肿瘤中的作用

王雯娟,何太平

  1. 湛江, 广东医学院生物化学与分子生物学研究所
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:何太平,E-mail:taipinghe@163.com E-mail:taipinghe@163.com
  • 基金资助:

    广东省自然科学基金资助项目( S2011010004146 )

Roles of the liver regeneration phosphatase-3 and its inhibitors in tumor

WANG Wen-juan, HE Tai-ping

  1. Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang 524023, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:HE Tai-ping, E-mail: taipinghe@163.com E-mail:taipinghe@163.com

摘要:肝再生磷酸酶-3(PRL-3)是新的小分子蛋白质酪氨酸磷酸酶,在肿瘤的发生发展中有重要作用。研究发现,PRL-3通过参与多种信号通路调控肿瘤进展。PRL-3在肿瘤组织中高表达能明显促进肿瘤转移,但在多数正常组织中不表达,因此有望成为肿瘤诊断的标志物及肿瘤治疗的新靶点。

关键词:蛋白质酪氨酸磷酸酶类,肿瘤,信号传导,酪氨酸磷酸化抑制剂

Abstract:Phosphatase of regenerating liver-3 (PRL-3) is a novel small molecule proteintyrosinephosphatase, which plays an important role in the oncogenesis and deveopment of tumors. Studies show that PRL-3 regulates neoplasm progress through participating in multiple signal pathways. Its high expression can significantly promote neoplasm metastasis in cancer tissue. However, there is no expression of PRL-3 in most normal tissue. PRL-3 is expected to be a potential tumor maker of diagnosis and a new target for the therapy of cancer.

Key words:Protein tyrosine phosphatases,Neoplasm,Signal transduction,Tyrphostins