国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (6): 418-421.

• 综述 •上一篇下一篇

肿瘤微环境相关17型辅助性T细胞

王辉,李杰,花宝金,孙桂芝

  1. 北京，中国中医科学院肿瘤研究所，中国中医科学院广安门医院肿瘤科
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:孙桂芝，E-mail:whongzhong@263.net E-mail:whongzhong@263.net
  • 基金资助:

    国家自然科学基金资助项目（81072790）

Tumor microenvironment related type 17 T helper cells

WANG Hui, LI Jie, HUA Bao-jin, SUN Gui-zhi

  1. Cancer Institute, China Academy of Chinese Medicine Sciences, Department of Oncology, Guang′anmen Hospital, China Academy of Chinese Medicine Sciences, Beijing 100053, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:SUN Gui-zhi, E-mail: whongzhong@263.net E-mail:whongzhong@263.net

PDF

1945

摘要：17型辅助性T细胞（Th17）是近年来发现的一种不同于传统1型和2型的CD4+效应T细胞，该细胞是由初始T细胞前体分化而来。肿瘤可通过免疫微环境中部分细胞因子招募外周血中Th17细胞至肿瘤局部，而Th17的分化进程也受到肿瘤微环境的精细调控。Th17对肿瘤生长等恶性生物学行为具有促进及抑制的双向作用。对Th17的进一步深入研究，将为肿瘤免疫研究提供新的切入点。

关键词:肿瘤,炎症,Th17细胞

Abstract:Type 17 T helper cells (Th17) are novel subsets of CD4+ effector T cells discovered recently which are different from the traditional type 1 and type 2. They are mainly differentiated from initial T cell precursor. Tumor microenvironmental cytokines can recruit CD4+ Th17 cells from the peripheral blood into tumor sites. And the differentiation of Th17 cells is also affected by tumor microenvironmental factors. Tumorinfiltrating Th17 cells play a dual role for tumor growth in both pro and antitumourigenic processes. A further understanding of the activities of Th17 cells will provide a new breakthrough point for the researches of cancer immunotherapy.

Key words:Neoplasms,Inflammation,Th17 cell