国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (6): 452-454.

• 综述 •上一篇下一篇

AIB家族在卵巢癌中的作用及机制

汪莲,李从铸,张灏

  1. 汕头大学医学院附属肿瘤医院妇瘤科(汪莲、李从铸)；汕头大学医学院附属肿瘤医院中西医结合科（张灏）
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:张灏，E-mail: haozhang@stu.edu.cn E-mail:haozhang@stu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目（30973508）；广东省高等学校人才引进项目（粤财教［2009］109）；广东省卫生厅科学基金项目（［2005］119）；汕市财文社会发展攻关计划项目（［2009］387、［2010］480）

The role of amplified in breast family and their research mechanisms in ovarian cancer

WANG Lian, LI Cong-zhu, ZHANG Hao

  1. Department of Gynecologic Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou 515041, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:ZHANG Hao, E-mail: haozhang@stu.edu.cn E-mail:haozhang@stu.edu.cn

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摘要：以乳腺癌扩增基因1（AIB1）为代表的AIB家族作为近年发现的共调节因子，在核受体参与的基因转录调节中发挥重要作用。AIB家族蛋白表达异常与多种肿瘤发生发展相关。最新研究证实，AIB家族成员在卵巢良恶性肿瘤中表达异常和扩增，提示AIB家族是卵巢癌发生发展中潜在的危险因素，可促进癌的进展。探究AIB家族在卵巢癌中的作用机制及意义，可以为卵巢癌的研究提供新的预后因子及治疗靶向。

关键词:卵巢肿瘤,基因,AIB家族

Abstract:The genes amplified in breast cancer family, as the novel defined hormone receptor co-activators, of which the key number is amplified in breast（AIB）1, is critical to the transcriptional activation function of nuclear hormone receptors. The abnormal expression of protein is related to the tumorigenesis and development of many tumors. Recently, emerging evidence suggests that the member of AIB family expresses abnormally and amplifies in ovarian tumors. Collectively, these results suggest that the AIB family is involved in the carcinogenesis and the development of ovarian cancers. Further research is required to explore the mechanism and significance as well as to determine the role of AIB family in ovarian cancers, which will potentially leading to a new prognostic marker and new therapeutic targets.

Key words:Ovarian neoplasms,Genes,The genes amplified in breast cancer family