沉默信息调节因子1在肿瘤发生发展中的作用

摘要/Abstract

摘要：沉默信息调节因子1（SIRT1）是一种依赖于烟酰胺腺嘌呤二核苷酸的组蛋白脱乙酰酶，参与肿瘤的发生发展过程。研究表明，SIRT1在胃癌、乳腺癌、前列腺癌等多种实体肿瘤中呈高表达，可促进肿瘤发生发展；同时发现，SIRT1在其他肿瘤如胶质母细胞瘤、膀胱癌、卵巢癌等中SIRT1表达降低，起抑癌基因的作用。因此，SIRT1的具体作用机制仍未阐明，尚存争议。

傅德强, 吴文艺, 张丽婷. 沉默信息调节因子1在肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2013, 40(12): 902-904.

FU De-Qiang, WU Wen-Yi, ZHANG Li-Ting. Roles of SIRT1 in tumorigenesis and tumor progression[J]. Journal of International Oncology, 2013, 40(12): 902-904.

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沉默信息调节因子1在肿瘤发生发展中的作用

Roles of SIRT1 in tumorigenesis and tumor progression

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