ZHX2与肿瘤的相关性研究

摘要/Abstract

摘要：转录抑制因子ZHX2是ZHX蛋白家族的成员之一，在人体组织中广泛存在，通过转录抑制作用参与多种疾病的发生与发展。研究表明ZHX2与肝癌、多发性骨髓瘤、胃癌、结直肠癌等的发生发展密切相关，具有肿瘤治疗的潜在价值。

付世杰, 郭庆河. ZHX2与肿瘤的相关性研究[J]. 国际肿瘤学杂志, 2013, 40(12): 905-907.

FU Shi-Jie, GUO Qing-He. ZHX2 and cancer[J]. Journal of International Oncology, 2013, 40(12): 905-907.

［1］ Kawata H, Yamada K, Shou Z, et al. Zincfingers and homeoboxes (ZHX) 2, a novel member of the ZHX family as a transcriptional repressor. Biochem J, 2003, 373 (Pt 3): 747757. ［2］ Shen H, Luan F, Liu H, et al. ZHX2 is a repressor of alphafetoprotein expression in human hepatoma cell lines. J Cell Mol Med, 2008, 12(68): 27722780. ［3］ Li MS, Li PF, He SP, et al. The promoting molecular mechanism of alphafetoprotein on the growth of human hepatoma Bel7402 cell line. World J Gastroenterol, 2002, 8(3): 469475. ［4］ Cavin LG, Venkatraman M, Factor VM, et al. Regulation of alphafetoprotein by nuclear factorkappaB protects hepatocytes from tumor necrosis factoralpha cytotoxicity during fetal liver development and hepatic oncogenesis. Cancer Res, 2004, 64 (19): 70307038. ［5］ Perincheri S, Dingle RW, Peterson ML, et al. Hereditary persistence of alphafetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene. Proc Natl Acad Sci USA, 2005, 102(2): 396401. ［6］ Lv Z, Zhang M, Bi J, et al. Promoter hypermethylation of a novel gene, ZHX2, in hepatocellular carcinoma. Am J Clin Pathol, 2006, 125(5): 740746. ［7］ Kittaka N, Takemasa I, Takeda Y, et al. Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic data. Eur J Cancer, 2008, 44(6): 885897. ［8］ Shirakawa H, Suzuki H, Shimomura M, et al. Glypican3 expression is correlated with poor prognosis in hepatocellular carcinoma. Cancer Sci, 2009, 100(8): 14031407. ［9］ Morford LA, Davis C, Jin L, et al. The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alphafetoprotein regulator 2. Hepatology, 2007, 46(5): 15411547. ［10］ Maurel M, Dejeans N, Taouji S, et al. MicroRNA1291mediated silencing of IRE1α enhances Glypican3 expression. RNA, 2013, 19(6): 778788. ［11］ Shih HC, Shiozawa T, Kato K, et al. Immunohistochemical expression of cyclins, cyclindependent kinases, tumorsuppressor gene products, Ki67, and sex steroid receptors in endometrial carcinoma: positive staining for cyclin A as a poor prognostic indicator. Hum Pathol, 2003, 34(5): 471478. ［12］ MüllerTidow C, Metzger R, Kügler K, et al. Cyclin E is the only cyclindependent kinase 2associated cyclin that predicts metastasis and survival in early stage nonsmall cell lung cancer. Cancer Res, 2001, 61(2): 647653. ［13］ Ohashi R, Gao C, Miyazaki M, et al. Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas. Anticancer Res, 2001, 21(1B): 657662. ［14］ Yue X, Zhang Z, Liang X, et al. Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclin A and E. Gastroenterology, 2012, 142(7): 15591570. ［15］ Gargalovic PS, Erbilgin A, Kohannim O, et al. Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism. Circ Cardiovasc Genet, 2010, 3(1): 6067. ［16］ Watts GS, Oshiro MM, Junk DJ, et al. The acetyltransferase p300/CBPassociated factor is a p53 target gene in breast tumor cells. Neoplasia, 2004, 6(3): 187194. ［17］ Cui R, Nguyen TT, Taube JH, et al. Family members p53 and p73 act together in chromatin modification and direct repression of alphafetoprotein transcription. J Biol Chem, 2005, 280(47): 3915239160. ［18］ Lu ZL, Luo DZ, Wen JM. Expression and significance of tumorrelated genes in HCC. World J Gastroenterol, 2005, 11(25): 38503854. ［19］ Aoki T, Miyamoto A, Marubashi S, et al. Clinical value of alterations in p73 gene, related to p53 at 1p36, in human hepatocellular carcinoma. Int J Oncol, 2004, 24(2): 441446. ［20］ Legartova S, HarnicarovaHorakova A, Bartova E, et al. Expression of RAN, ZHX2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors. Neoplasma, 2010, 57(5): 482487. ［21］ Armellini A, Sarasquete ME, GarcíaSanz R, et al. Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma. Br J Haematol, 2008, 141(2): 212215. ［22］魏晶晶, 吕自力, 党裔武, 等. 结直肠癌中ZHX2蛋白表达的检测及其临床病理意义. 临床与实验病理学杂志, 2012, 28(2): 128131. ［23］ Hoffman WH, Biade S, Zilfou JT, et al. Transcriptional repression of the antiapoptotic surviving gene by wild type p53. J Biol Chem, 2002, 277(5): 32473257. ［24］ Morachis JM, Murawsky CM, Emerson BM. Regulation of the p53 transcription response by structurally diverse core promoters. Genes Dev, 2010, 24(2): 135147. ［25］陈其军, 吕自力, 党裔武, 等. 转录抑制因子ZHX2在胃癌组织中的表达及临床意义. 世界华人消化杂志, 2011, 19 (30): 31633167.

[1]	刘娜, 寇介丽, 杨枫, 刘桃桃, 李丹萍, 韩君蕊, 杨立洲.血清miR-106b-5p、miR-760联合低剂量螺旋CT诊断早期肺癌的临床价值[J]. 国际肿瘤学杂志, 2024, 51(6): 321-325.
[2]	杨蜜, 别俊, 张加勇, 邓佳秀, 唐组阁, 卢俊.局部晚期可切除食管癌新辅助治疗疗效及预后分析[J]. 国际肿瘤学杂志, 2024, 51(6): 332-337.
[3]	袁健, 黄燕华.Hp-IgG抗体联合血清DKK1、sB7-H3对早期胃癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(6): 338-343.
[4]	陈红健, 张素青.血清miR-24-3p、H2AFX与肝癌患者临床病理特征及术后复发的关系研究[J]. 国际肿瘤学杂志, 2024, 51(6): 344-349.
[5]	郭泽浩, 张俊旺.PFDN及其亚基在肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2024, 51(6): 350-353.
[6]	张百红, 岳红云.新作用机制的抗肿瘤药物进展[J]. 国际肿瘤学杂志, 2024, 51(6): 354-358.
[7]	许凤琳, 吴刚.EBV在鼻咽癌肿瘤免疫微环境和免疫治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 359-363.
[8]	王盈, 刘楠, 郭兵.抗体药物偶联物在转移性乳腺癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 364-369.
[9]	张蕊, 褚衍六.基于FIT与肠道菌群的结直肠癌风险评估模型的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 370-375.
[10]	高凡, 王萍, 杜超, 褚衍六.肠道菌群与结直肠癌非手术治疗的相关研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 376-381.
[11]	王丽, 刘志华, 杨伟洪, 蒋凤莲, 李全泳, 宋浩杰, 鞠文东.ROS1突变肺腺鳞癌合并脑梗死为主要表现的Trousseau综合征1例[J]. 国际肿瘤学杂志, 2024, 51(6): 382-384.
[12]	刘静, 刘芹, 黄梅.基于SMOTE算法的食管癌放化疗患者肺部感染的预后模型构建[J]. 国际肿瘤学杂志, 2024, 51(5): 267-273.
[13]	杨琳, 路宁, 温华, 张明鑫, 朱琳.炎症负荷指数与胃癌临床关系研究[J]. 国际肿瘤学杂志, 2024, 51(5): 274-279.
[14]	王俊毅, 洪楷彬, 纪荣佳, 陈大朝.癌结节对结直肠癌根治性切除术后肝转移的影响[J]. 国际肿瘤学杂志, 2024, 51(5): 280-285.
[15]	张宁宁, 杨哲, 檀丽梅, 李振宁, 王迪, 魏永志.宫颈细胞DNA倍体分析联合B7-H4和PKCδ对宫颈癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(5): 286-291.

ZHX2 and cancer

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章15

编辑推荐

Metrics

本文评价