M2型丙酮酸激酶在肿瘤代谢中的作用

摘要/Abstract

摘要：M2型丙酮酸激酶（PKM2）是糖酵解途径的一个关键限速酶，在多种恶性肿瘤细胞中高表达。在肿瘤糖代谢通路中，PKM2可以通过在高活性的四聚体和低活性的二聚体之间相互转化，促进肿瘤的糖酵解和细胞增殖。肿瘤细胞通过多种方式调节PKM2的表达和酶活性如转录调节、变构调节和翻译后修饰调节。PKM2在肿瘤发生和肿瘤代谢中的重要作用使它有望成为肿瘤治疗的新靶点。

关键词:丙酮酸激酶,肿瘤,糖酵解,M2型丙酮酸激酶

Abstract:The M2type of pyruvate kinase (PKM2) is a key ratelimiting enzyme in glycolytic pathway, and is highly expressed in diverse tumor cells. In glycometabolism pathway of tumor, PKM2 can promote glycolysis and tumor cells growth through the mutual transformation between highly active tetramer and lowly active dimer. Tumor cells can regulate PKM2 expression and enzymatic activity through many mechanisms, such as transcription regulation, allosteric regulation and posttranslational modification. PKM2 is expected to be a new target for oncotherapy because of its vital function in tumorigenesis and tumor metabolism.

Key words:Pyruvate kinase,Neoplasms,Glycolysis,M2type pyruvate kinase

王娟, 程斌. M2型丙酮酸激酶在肿瘤代谢中的作用[J]. 国际肿瘤学杂志, 2014, 41(1): 17-20.

Wang Juan, Cheng Bin. Role of M2type pyruvate kinase in the metabolism of tumor[J]. Journal of International Oncology, 2014, 41(1): 17-20.

参考文献

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