国际肿瘤学杂志››2014,Vol. 41››Issue (1): 21-23.doi:10.3760/cma.j.issn.1673-422X.2014.01.007

• 综述 •上一篇下一篇

maspin基因与肿瘤靶向治疗

曹玲, 钱亚云, 刘延庆

  1. 225001扬州大学医学院中西医结合临床医学系肿瘤研究室
  • 出版日期:2014-01-08发布日期:2014-01-22
  • 通讯作者:刘延庆,E-mail:liuyq@yzu.edu.cn E-mail:liuyq@yzu.edu.cn
  • 基金资助:

    国家自然科学基金(81274141);江苏省自然科学基金(BK2012686)

Maspin and target therapy of tumor

Cao Ling, Qian Yayun, Liu Yanqing

  1. Cancer Research Institute, Department of Integrative Medicine, Medical School, Yangzhou University, Yangzhou 225001, China
  • Online:2014-01-08Published:2014-01-22
  • Contact:Liu Yanqing E-mail:liuyq@yzu.edu.cn

摘要:maspin是一种抑癌基因,属于丝氨酸蛋白酶抑制剂超家族成员,能抑制肿瘤细胞生长、侵袭和转移,促进肿瘤细胞凋亡,影响肿瘤血管生成以及增加化疗敏感性。对maspin靶向治疗肿瘤的机制深入研究可为肿瘤治疗提供新的思路。

关键词:基因,肿瘤,靶向治疗

Abstract:Maspin, a member of the serine protease inhibitor superfamily, is considered to be a tumor suppressor. Maspin can inhibit the tumor cells growth, invasion and metastasis, promote apoptosis of the tumor cells, affect tumor angiogenesis and increase the sensitivity of chemotherapy. The indepth study of the target therapy mechanisms of maspin can provide new ideas for tumor treatment.

Key words:Genes,Neoplasms,Target therapy