鼻咽癌放疗相关第二原发口腔癌的研究进展

摘要/Abstract

摘要：放疗作为鼻咽癌（NPC）的主要治疗方法已使其得到有效控制，但由于与鼻咽部解剖位置临近，放疗引起的口腔并发症非常普遍，口腔第二原发癌(SPM)已成为导致NPC患者最终生存率低的重要原因。SPM的发病机制尚未完全明确，患者预后较差，对其的研究仍在探索中。

赵楠, 吴桐, 程斌. 鼻咽癌放疗相关第二原发口腔癌的研究进展[J]. 国际肿瘤学杂志, 2016, 43(2): 145-.

ZHAO Nan, WU Tong, CHENG Bin. Research advances on second primary malignancies of oral cavity following radiotherapy for nasopharyngeal carcinoma[J]. Journal of International Oncology, 2016, 43(2): 145-.

参考文献

［1］ Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012［J］. Int J Cancer, 2015, 136(5): E359386. DOI:10.1002/ijc.29210. ［2］ Bray F, Jemal A, Grey N, et al. Global cancer transitions according to the human development index (20082030): a populationbased study［J］. Lancet Oncol, 2012, 13(8): 790801. DOI:10.1016/S14702045(12)702115. ［3］ Jemal A, Bray F, Center MM, et al. Global cancer statistics［J］. CA Cancer J Clin, 2011, 61(2): 6990. DOI:10.3322/caac.20107. ［4］ Cao SM, Simons MJ, Qian CN. The prevalence and prevention of nasopharyngeal carcinoma in China［J］. Chin J Cancer, 2011, 30(2): 114119. ［5］ Chen L, Hu CS, Chen XZ, et al. Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial［J］. Lancet Oncol, 2012, 13(2): 163171. DOI:10.1016/S14702045(11)703205. ［6］ Macready N. Looking treatment complications in the mouth［J］. J Natl Cancer Inst, 2013, 105(2): 7677. DOI:10.1093/jnci/djs643. ［7］ Zhang L, Zhao C, Ghimire B, et al. The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a metaanalysis of the phase Ⅲ randomized trials［J］. BMC Cancer, 2010, 10(1): 558. DOI:10.1186/1471240710558. ［8］黄引芳, 傅深, 章青, 等. 白细胞介素11预防和治疗头颈部肿瘤放疗导致口腔黏膜反应的疗效观察［J］. 国际肿瘤学杂志, 2010, 37(9): 710712 ［9］ Xi M, Liu SL, Zhao L, et al. Prognostic factors and survival in patients with radiationrelated second malignant neoplasms following radiotherapy for nasopharyngeal carcinoma［J］. PLoS One, 2013, 8(12): e84586. DOI:10.1371/journal.pone.0084586. ［10］ Song M, Zhuang SM, Chen SW, et al. Survival study and treatment strategy for second primary tumors in the oral cavity in patients with nasopharyngeal carcinoma after definitive radiation［J］. Head Neck, 2012, 34(11): 15511555. DOI:10.1002/hed.21959. ［11］ Kong L, Lu JJ, Hu C, et al. The risk of second primary tumors in patients with nasopharyngeal carcinoma after definitive radiotherapy［J］. Cancer, 2006, 107(6): 12871293. DOI:10.1002/cncr.22119. ［12］ Wang CC, Chen ML, Hsu KH, et al. Second malignant tumors in patients with nasopharyngeal carcinoma and their association with EpsteinBarr virus［J］. Int J Cancer, 2000, 87(2): 228231. ［13］ Chan JY, Gooi Z, Mydlarz WK, et al. Risk of second primary malignancy after nasopharyngeal carcinoma in the United States: a populationbased study［J］. Head Neck, 2015, in press. DOI:10.1002/hed.24173. ［14］ Lin C, Lin SW, Weng SF, et al. Risk of second primary malignancies after nasopharyngeal carcinoma: a populationbased cohort study in Taiwan［J］. Head Neck, 2014, 36(2): 209214. DOI:10.1002/hed.23281. ［15］ Chen MC, Feng IJ, Lu CH, et al. The incidence and risk of second primary cancers in patients with nasopharyngeal carcinoma: a populationbased study in Taiwan over a 25year period (19792003)［J］. Ann Oncol, 2008, 19(6): 11801186. DOI:10.1093/annonc/mdn003. ［16］ Sun C, Hu Z, Zhong Z, et al. Clinical and prognostic analysis of second primary squamous cell carcinoma of the tongue after radiotherapy for nasopharyngeal carcinoma［J］. Br J Oral Maxillofac Surg, 2014, 52(8): 715720. DOI:10.1016/j.bjoms.2014.06.015. ［17］ Teo PM, Chan AT, Leung SF, et al. Increased incidence of tongue cancer after primary radiotherapy for nasopharyngeal carcinomathe possibility of radiation carcinogenesis［J］. Eur J Cancer, 1999, 35(2): 219225. ［18］孙传政, 陈福进, 曾宗渊, 等. 第一原发性舌癌和鼻咽癌放疗后第二原发性舌癌的比较分析［J］. 中华肿瘤杂志, 2006, 28(12): 938941 ［19］ Cha C, Antonescu CR, Quan ML, et al. Longterm results with resection of radiationinduced soft tissue sarcomas［J］. Ann Surg, 2004, 239(6): 903909. ［20］ Robbins KT, Samant S, Vieira F, et al. Presurgical cytoreduction of oral cancer using intraarterial cisplatin and limited concomitant radiation therapy (NeoRADPLAT)［J］. Arch Otolaryngol Head Neck Surg, 2004, 130(1): 2832. DOI:10.1001/archotol.130.1.28. ［21］ Rennemo E, Ztterstrm U, Boysen M. Impact of second primary tumors on survival in head and neck cancer: an analysis of 2 063 cases［J］. Laryngoscope, 2008, 118(8): 13501356. DOI:10.1097/MLG.0b013e318172ef9a. ［22］叶玲, 刘晓清, 周琦超, 等. 个体化口腔支架在鼻咽癌患者调强放疗中应用的剂量分析［J］. 中山大学学报:医学科学版, 2014, 35(1): 7479 ［23］ Berrington De Gonzalez A, Curtis RE, Kry SF, et al. Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US Seer cancer registries［J］. Lancet Oncol, 2011, 12(4): 353360. DOI:10.1016/S14702045(11)700614. ［24］ Goggins WB, Yu IT, Tse LA, et al. Risk of second primary malignancies following nasopharyngeal carcinoma in Hong Kong［J］. Cancer Causes Control, 2010, 21(9): 14611466. DOI:10.1007/s105520109574x. ［25］ Scélo G, Boffetta P, Corbex M, et al. Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries［J］. Cancer Causes Control, 2007, 18(3): 269278. DOI:10.1007/s105520060101z. ［26］ Lv P, Wang Y, Ma J, et al. Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair［J］. Oncotarget, 2014, 5(17): 75127524.

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