Journal of International Oncology››2015,Vol. 42››Issue (2): 126-129.doi:10.3760/cma.j.issn.1673-422X.2015.02.012

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Microenvironment and the occurrence and development of cancer stem cells

hang Xiaoying, Wang Xiaofang

  1. Department of Hematology, Tianjin Medical University Cancer Hospital, National Cancer Clinical Medical Research Center, Key Labrotary of Cancer Prevention and Therapy, Tianjin 300060, China
  • Online:2015-02-08Published:2015-02-02
  • Contact:Wang Xiaofang E-mail:xiaofangwang2005@163.com

Abstract:The occurrence and development of tumor depends not only on the tumor itself, but also depends on the soil survival of tumor cells, that is the tumor microenvironment. Studies confirm that the changes of blood vessels and hypoxic of tumor microenvironment maintain the stemness of cancer stem cell, and further strengthen the ability of tumor invasion and metastasis. Studying the molecular mechanism of tumor development from angiogenesis and lack of oxygen can provide new ideas for the clinical targeted therapy.

Key words:Neoplastic stem cells,Neovascularization, pathologic,Cell hypoxia,Tumor microenvironment