Journal of International Oncology

Journal of International Oncology››2011,Vol. 38››Issue (11): 816-818.

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Effects of insulinoma-glucagonoma clone 20 isoforms on cancer cells

WEI Yu-Ping, DONG Liang, BI Wen-Xiang

  1. Department of Biochemistry and Molecular Biology of Medical School, Shandong University, Jinan 250012，China
  • Online:2011-11-08Published:2011-11-03

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Abstract:Insulinoma-glucagonoma clone 20 can express at least 6 isoforms in human cells. These isoforms can affect cell apoptosis and proliferation through apoptosis related signaling pathway, such as TRAIL or TNF signaling pathways. Furthermore, insulinoma-glucagonoma clone 20, as a GTP-GDP exchange factor, participates in the transportation of nerve synaptophysins.