Abstract:MicroRNAs (miRNAs) are a class of small non-coding RNAs which involve in the regulation after gene transplantation. Researches show that miRNA is closely related to the development and progression of non–small-cell lung cancer (NSCLC). They caused a significantly change in NSCLC cells through downregulate tumor suppressor gene, or act as oncogene or work on some targets which is important in cell signal pathway, in the end it lead to oncogenesis, cell proliferation, cell apoptosis and resistance to chemotherapy or radiotherapy. Therefore, miRNA will be hopefully used in the diagnose and therapy of cancer.

Key words:Carcinoma, non-small-cell lung,MicroRNAs