Journal of International Oncology››2012,Vol. 39››Issue (6): 415-417.

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Roles of the liver regeneration phosphatase-3 and its inhibitors in tumor

WANG Wen-juan, HE Tai-ping

  1. Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang 524023, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:HE Tai-ping, E-mail: taipinghe@163.com E-mail:taipinghe@163.com

Abstract:Phosphatase of regenerating liver-3 (PRL-3) is a novel small molecule proteintyrosinephosphatase, which plays an important role in the oncogenesis and deveopment of tumors. Studies show that PRL-3 regulates neoplasm progress through participating in multiple signal pathways. Its high expression can significantly promote neoplasm metastasis in cancer tissue. However, there is no expression of PRL-3 in most normal tissue. PRL-3 is expected to be a potential tumor maker of diagnosis and a new target for the therapy of cancer.

Key words:Protein tyrosine phosphatases,Neoplasm,Signal transduction,Tyrphostins